{"id":"W2737966837","doi":"10.1016/j.bbamem.2017.07.009","title":"Mechanisms of pannexin1 channel gating and regulation","year":2017,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University","funders":"","keywords":"Pannexin; Gating; Context (archaeology); Biology; Neuroscience; Cell biology; Gene isoform; Intracellular; Extracellular; Integral membrane protein; Gap junction; Computational biology; Connexin; Membrane protein; Gene; Genetics; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005241185,0.0007342537,0.001043468,0.0009634637,0.0002406438,0.0010277,0.0008651022,0.0009092006,0.002114846],"category_scores_gemma":[0.0004917589,0.0002231924,0.0002614784,0.001070468,0.000631402,0.001565423,0.0008680525,0.001239778,0.001154889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006436786,"about_ca_system_score_gemma":0.0009819831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005418153,"about_ca_topic_score_gemma":0.0009072216,"domain_scores_codex":[0.9998848,0.00001401223,0.00001733785,0.00002406718,0.00004026659,0.00001945129],"domain_scores_gemma":[0.999868,0.00005308506,0.00002318467,0.000005676382,0.00003499515,0.00001485679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001195204,0.00004375,0.0002306731,0.01588882,0.00007683338,0.0003838533,0.0001059587,0.0005787188,0.007734724,0.01364736,0.02706101,0.9341288],"study_design_scores_gemma":[0.00001490734,0.0000466456,0.0006758532,0.001743289,0.00009375666,0.001129131,0.00006899161,0.00015691,0.001958719,0.005546307,0.9885458,0.00001985056],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002194997,0.9978949,0.0002933972,0.0003360806,0.0002115584,0.000004251684,0.00002254815,0.000007979499,0.001009784],"genre_scores_gemma":[0.001038145,0.9978765,0.000172265,0.000136343,0.0001659725,0.000006570513,0.00003234216,0.000001136074,0.0005706477],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002114846,"threshold_uncertainty_score":0.007074833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06204805767144102,"score_gpt":0.3432549446611816,"score_spread":0.2812068869897406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}