{"id":"W2738009647","doi":"10.1056/nejmc1705994","title":"ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia","year":2017,"lang":"en","type":"letter","venue":"New England Journal of Medicine","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":329,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi","funders":"","keywords":"Medicine; Familial hypercholesterolemia; Internal medicine; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001037447,0.0003948086,0.001549449,0.0008288597,0.00005767779,0.00002592338,0.0002172195,0.0006840208,0.0002911596],"category_scores_gemma":[0.0009842238,0.0002625583,0.0002111769,0.0001297642,0.0002409405,0.0001928142,0.00003902183,0.003510977,0.00002647634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001003165,"about_ca_system_score_gemma":0.0006222402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004282301,"about_ca_topic_score_gemma":0.00006123148,"domain_scores_codex":[0.9970467,0.000160506,0.001040543,0.0002774079,0.001052735,0.0004221161],"domain_scores_gemma":[0.9978737,0.0001671456,0.000872364,0.0005186051,0.0002562952,0.0003118727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006159908,0.00004875196,0.001195802,0.0002133961,0.00007306371,0.0175534,0.0006792102,0.000001904084,0.00059062,0.000003065276,0.9126219,0.06640286],"study_design_scores_gemma":[0.07409697,0.001046238,0.004700655,0.002742165,0.0005556034,0.01163291,0.00007823367,0.00000251577,0.00004742422,0.0004664283,0.9044259,0.000205011],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.151246,0.005566326,0.00008093512,0.8302878,0.004608169,0.0003422487,0.00001335334,0.00001945661,0.007835771],"genre_scores_gemma":[0.1186296,0.003111417,0.0004044825,0.6443672,0.2220526,0.000005297374,0.0002804131,0.0001400237,0.01100894],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2174445,"threshold_uncertainty_score":0.9999827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02497365268085234,"score_gpt":0.2851158381122514,"score_spread":0.2601421854313991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}