{"id":"W2738037027","doi":"","title":"SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome","year":2016,"lang":"en","type":"article","venue":"The Molecular Biology Society of Japan","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Université de Montréal; McGill University; Montreal Heart Institute; University of Toronto; Montreal Neurological Institute and Hospital","funders":"","keywords":"mitochondrial fusion; MFN2; Cell biology; DNAJA3; Mitochondrion; MFN1; Biology; Mitochondrial fission; Endoplasmic reticulum; Mitochondrial carrier; ATP–ADP translocase; Inner mitochondrial membrane; Mitochondrial membrane transport protein; Proteostasis; Translocase of the inner membrane; Bacterial outer membrane; Biochemistry; Mitochondrial DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009763158,0.0006776362,0.0002442696,0.0004915213,0.0003093822,0.0001939912,0.0001962036,0.0004492799,0.00148769],"category_scores_gemma":[0.000293259,0.0001324368,0.000288049,0.0003306337,0.0003494884,0.0001598773,0.0002577534,0.0002341863,0.0003377961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001849116,"about_ca_system_score_gemma":0.0002118934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001562483,"about_ca_topic_score_gemma":0.001230727,"domain_scores_codex":[0.9998648,0.00002697343,0.00002373533,0.0000341852,0.00003395415,0.0000163093],"domain_scores_gemma":[0.9998517,0.0000181634,0.00006694606,0.00001179958,0.0000103071,0.00004110958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004435374,0.00003651277,0.02299761,0.0001273665,0.00009224127,0.02180259,0.000214773,0.0004240635,0.9443332,0.0007399276,0.0006303815,0.008157808],"study_design_scores_gemma":[0.0001597699,0.0004602789,0.3242839,0.0001172134,0.0004535787,0.1489518,0.0004703025,0.008633806,0.4914669,0.002099185,0.022821,0.00008228362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950441,0.001287063,0.002064775,0.0001774223,0.00003920025,0.00001429051,0.0003780844,0.0001729959,0.0008221688],"genre_scores_gemma":[0.9981751,0.0002574738,0.0007274177,0.00003275408,0.00001472256,0.000006219406,0.000240544,0.00001470534,0.0005308975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001562483,"threshold_uncertainty_score":0.004976869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01567831772858509,"score_gpt":0.2726633976672577,"score_spread":0.2569850799386726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}