{"id":"W2738098949","doi":"10.3748/wjg.v23.i27.4958","title":"Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn’s disease","year":2017,"lang":"en","type":"article","venue":"World Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Louisville","keywords":"Single-nucleotide polymorphism; Medicine; Internal medicine; Genotype; Odds ratio; Minor allele frequency; Gastroenterology; Crohn's disease; Prospective cohort study; Confounding; Immunology; Disease; Biology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002416403,0.0002439059,0.0003350926,0.0003015684,0.0001293152,0.00006379448,0.0005555315,0.00004668674,0.00006802429],"category_scores_gemma":[0.0002367744,0.0002171922,0.0002363482,0.00003243501,0.0001526179,0.00001393726,0.000167523,0.0001169785,0.00001171002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001032949,"about_ca_system_score_gemma":0.0002117743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001733593,"about_ca_topic_score_gemma":0.0006970789,"domain_scores_codex":[0.9982191,0.0003169277,0.0005267749,0.0003001409,0.0001666889,0.0004703697],"domain_scores_gemma":[0.9981877,0.00001411918,0.0004629467,0.0006931233,0.00009764263,0.0005444441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0317518,0.0002416066,0.9160783,0.000006387213,0.0000837611,0.004596608,0.00004359133,0.0002041642,0.04604576,0.000001280825,0.0005849092,0.0003618093],"study_design_scores_gemma":[0.003050806,0.00133575,0.9926299,0.00003861772,0.00004979886,0.000111334,0.000007615325,0.0000164438,0.0008418156,0.00001167635,0.001795952,0.0001102589],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976244,0.00007440997,0.0001595363,0.001340902,0.0004311007,0.0002570689,0.0000891918,0.000004323588,0.00001904434],"genre_scores_gemma":[0.9980233,0.00003285925,0.0003650003,0.0007924743,0.0003176265,0.00002314311,0.000003856479,0.00003112458,0.0004106481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07655162,"threshold_uncertainty_score":0.8856841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009378195512407888,"score_gpt":0.2504380394065042,"score_spread":0.2410598438940963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}