{"id":"W2738136796","doi":"10.1016/s0140-6736(17)31613-6","title":"Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal women with osteoporosis transitioning from oral bisphosphonate therapy: a randomised, open-label, phase 3 trial","year":2017,"lang":"en","type":"article","venue":"The Lancet","topic":"Bone health and osteoporosis research","field":"Medicine","cited_by":467,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Centre hospitalier de l'Université Laval; Université Laval","funders":"","keywords":"Teriparatide; Sclerostin; Medicine; Osteoporosis; Open label; Internal medicine; Postmenopausal osteoporosis; Denosumab; Oncology; Monoclonal antibody; Bisphosphonate; Antibody; Clinical trial; Immunology; Bone mineral; Wnt signaling pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001593157,0.001937204,0.003543493,0.0004547557,0.0004321404,0.001178775,0.0007581768,0.002342842,0.006904054],"category_scores_gemma":[0.001646337,0.0007884811,0.002862937,0.0005099698,0.001352449,0.001240491,0.0004136847,0.003776064,0.001283302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007036431,"about_ca_system_score_gemma":0.0008437908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001390756,"about_ca_topic_score_gemma":0.003000892,"domain_scores_codex":[0.9994666,0.0002484731,0.00003460585,0.0001028161,0.00004433655,0.0001032026],"domain_scores_gemma":[0.9993292,0.0002445776,0.0001304622,0.00005007251,0.00003780516,0.0002079787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9827906,0.001616659,0.0002996783,0.0006313386,0.0009893166,0.00004150659,0.00004348754,0.00019867,0.002252483,0.00009772947,0.0006122973,0.01042634],"study_design_scores_gemma":[0.9770184,0.02093233,0.0007318188,0.00002837623,0.0004163531,0.00002795421,0.00001931162,0.0001666926,0.0001496156,0.000145813,0.0003534249,0.000009713403],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738115,0.01436546,0.0009854927,0.001947459,0.001240933,0.002966385,0.001631349,0.000227306,0.002824094],"genre_scores_gemma":[0.9816288,0.006256158,0.00161607,0.001898598,0.0007073423,0.002641288,0.001349723,0.0000374213,0.003864629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006904054,"threshold_uncertainty_score":0.02309638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1271756402788979,"score_gpt":0.4201141180026649,"score_spread":0.292938477723767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}