{"id":"W2738156861","doi":"10.1038/ncb3582","title":"ARID1A-mutated ovarian cancers depend on HDAC6 activity","year":2017,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":231,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"ARID1A; Cancer research; HDAC6; Biology; Chromatin; Mutation; Epigenetics; Psychological repression; Protein subunit; Histone; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000252154,0.000344287,0.0002631967,0.0003312843,0.0002159268,0.0007597017,0.0004508624,0.0002929625,0.004004173],"category_scores_gemma":[0.0003486196,0.0002630617,0.000329402,0.0002262593,0.000448717,0.0003805114,0.00044797,0.000535597,0.001523227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005030833,"about_ca_system_score_gemma":0.0002326196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004920177,"about_ca_topic_score_gemma":0.0008822406,"domain_scores_codex":[0.9996275,0.00004816993,0.0000461864,0.00007625018,0.0001139536,0.00008792862],"domain_scores_gemma":[0.9996433,0.00004591091,0.00009701031,0.00006797654,0.00003706936,0.0001086904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002701471,0.00002210886,0.003671545,0.00004306422,0.00002482005,0.0002628764,0.000008583161,0.0001171982,0.9914237,0.0005752902,0.0002886546,0.00329203],"study_design_scores_gemma":[0.00003162036,0.0001005305,0.03065613,0.000007337052,0.00002797049,0.002654532,0.00004400879,0.001111089,0.9572029,0.000514676,0.007641426,0.000007822722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810842,0.005510042,0.003583566,0.0008376209,0.0002039084,0.00001771194,0.002273412,0.0004407657,0.006048914],"genre_scores_gemma":[0.9954547,0.0006513533,0.0008818721,0.00008176921,0.00001785541,0.000006666325,0.0007126571,0.00005560447,0.002137557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004004173,"threshold_uncertainty_score":0.01339531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008569571080236914,"score_gpt":0.2921513207555779,"score_spread":0.283581749675341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}