{"id":"W2738203668","doi":"10.1534/genetics.117.1132","title":"Histone Acetylation, Not Stoichiometry, Regulates Linker Histone Binding in<i>Saccharomyces cerevisiae</i>","year":2017,"lang":"en","type":"article","venue":"Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chromatin; Biology; Histone H2A; Histone H1; Histone; Histone code; Histone methyltransferase; Histone octamer; Acetylation; Cell biology; Chromatin immunoprecipitation; Histone methylation; Saccharomyces cerevisiae; Histone H3; Genetics; Nucleosome; Yeast; Gene expression; Gene; Promoter; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002503406,0.000245439,0.0002501151,0.0001161838,0.0003417257,0.0001263164,0.0006309545,0.0002601648,0.00003182155],"category_scores_gemma":[0.0001016259,0.0002679055,0.0001008028,0.00008031507,0.0001627114,0.00000730042,0.000361421,0.0001381775,0.00003559161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006928481,"about_ca_system_score_gemma":0.0000835049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002927432,"about_ca_topic_score_gemma":0.0002199927,"domain_scores_codex":[0.9985476,0.00003323214,0.0003863596,0.0004829635,0.000179243,0.0003706095],"domain_scores_gemma":[0.9983417,0.00001065403,0.0003269969,0.001120394,0.00009531611,0.0001048714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003073886,0.00007080885,0.02450647,0.00004640445,0.0000488072,0.000006149531,0.0001132897,0.0005857626,0.9666116,0.000112879,0.001558994,0.006308054],"study_design_scores_gemma":[0.002825507,0.0004320903,0.2675669,0.0001111833,0.0001002496,0.00006341952,0.0001662838,0.004512279,0.6075355,0.0005764638,0.1146115,0.001498564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956815,0.00180765,0.0003184243,0.0005059437,0.0003997638,0.0001948938,0.00004042867,0.00001400747,0.001037422],"genre_scores_gemma":[0.9901329,0.001150429,0.00594044,0.0001354651,0.0002983001,0.00001314663,0.0001570221,0.00005335915,0.002118895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3590761,"threshold_uncertainty_score":0.9999773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01441042284855948,"score_gpt":0.2865621379891394,"score_spread":0.27215171514058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}