{"id":"W2738241641","doi":"10.1007/s10637-017-0488-2","title":"Copper (II) complexes of bidentate ligands exhibit potent anti-cancer activity regardless of platinum sensitivity status","year":2017,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Centre for Drug Research and Development; BC Cancer Agency","funders":"BC Cancer Agency; Canadian Cancer Society Research Institute","keywords":"Clioquinol; Plumbagin; Platinum; Carboplatin; Cisplatin; Copper; Chemistry; Denticity; Pharmacology; Cancer research; Chemotherapy; Biochemistry; Medicine; Internal medicine; Biology; Metal; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003776621,0.0001970866,0.0006191439,0.0000912347,0.0002803961,0.00003405494,0.0001325317,0.00007351411,0.000138335],"category_scores_gemma":[0.0003645531,0.0001600335,0.0001609619,0.00006773885,0.0006660968,0.0002520874,0.0001714243,0.0001556715,0.000008871905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004418834,"about_ca_system_score_gemma":0.0004610819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004503854,"about_ca_topic_score_gemma":0.0001198133,"domain_scores_codex":[0.9983682,0.00007247807,0.0004100225,0.0002788787,0.0006309757,0.0002394299],"domain_scores_gemma":[0.9982432,0.0001561508,0.0005882294,0.0004958289,0.0002819918,0.0002345839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002268386,0.0001124825,0.07000051,0.000202604,0.0001414921,0.00000366265,0.000686769,0.00008015225,0.9222398,0.001154864,0.001898289,0.003252522],"study_design_scores_gemma":[0.0007348483,0.00008033384,0.3337199,0.0003417459,0.00006688452,0.000008009127,0.00004926341,0.0004173554,0.6629383,0.0007384691,0.0007869452,0.0001179046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939783,0.0002087022,0.00003024731,0.002662079,0.0001479633,0.0002512947,0.0001784029,0.00002067484,0.002522327],"genre_scores_gemma":[0.9960438,0.00008903814,0.001173348,0.0002276315,0.0001741145,0.000006739258,0.00002879237,0.00002208659,0.002234425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2637194,"threshold_uncertainty_score":0.6808509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0754335186395352,"score_gpt":0.3180040468573997,"score_spread":0.2425705282178645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}