{"id":"W2738332138","doi":"","title":"cIAP2 is a K63 ubiquitin ligase for RIP1 which is blocked by IAP BIR antagonists during death receptor-mediated apoptosis","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Aegera Therapeutics (Canada)","funders":"","keywords":"XIAP; Inhibitor of apoptosis; Cell biology; Ubiquitin ligase; Signal transducing adaptor protein; Caspase; Autocrine signalling; Apoptosis; Caspase 8; Programmed cell death; Biology; Cancer cell; Ubiquitin; Cancer research; Signal transduction; Chemistry; Receptor; Cancer; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001229992,0.000428507,0.0003466604,0.0002122523,0.0002476892,0.0002729563,0.0003295744,0.000292627,0.003280073],"category_scores_gemma":[0.0001104567,0.000124185,0.0003149774,0.000182031,0.0001616498,0.0002300156,0.0001943619,0.0006620826,0.001426507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005429754,"about_ca_system_score_gemma":0.0002447293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004264665,"about_ca_topic_score_gemma":0.0004194606,"domain_scores_codex":[0.9998203,0.00002395146,0.00001724125,0.00002799425,0.00004415569,0.00006641387],"domain_scores_gemma":[0.99994,0.000005221636,0.00001546285,0.000006521987,0.00001023728,0.00002248791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001985573,0.00002737346,0.0001321074,0.00006194473,0.00001139753,0.000148803,0.000007307631,0.00006928897,0.9957045,0.0001746709,0.0003111423,0.003152875],"study_design_scores_gemma":[0.00002864052,0.0002141684,0.002214342,0.000005319947,0.00001272328,0.001666626,0.00001390314,0.0007928911,0.9860635,0.00004713768,0.00893498,0.000005797604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9561318,0.01398093,0.01194398,0.0004873902,0.000194465,0.0001767264,0.001884258,0.0005424267,0.014658],"genre_scores_gemma":[0.9865515,0.002258568,0.003267902,0.0001259827,0.0000164627,0.00007138329,0.001783689,0.00002499231,0.005899566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003280073,"threshold_uncertainty_score":0.01097292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04339988113048004,"score_gpt":0.3518094651140785,"score_spread":0.3084095839835984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}