{"id":"W2738418450","doi":"10.2337/db16-1585","title":"NADPH Oxidase Nox5 Accelerates Renal Injury in Diabetic Nephropathy","year":2017,"lang":"en","type":"article","venue":"Diabetes","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Medical Research Council; British Heart Foundation; Juvenile Diabetes Research Foundation International","keywords":"Renal injury; Diabetic nephropathy; Medicine; NADPH oxidase; Nephropathy; Internal medicine; Endocrinology; Urology; Diabetes mellitus; Kidney; Oxidative stress","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004906242,0.000434835,0.0003974896,0.0003815457,0.0001793143,0.0003152352,0.0002249406,0.0004088682,0.0015277],"category_scores_gemma":[0.0001476973,0.0001462368,0.0005292494,0.0002378747,0.0001854544,0.0002904083,0.0003247122,0.0008197672,0.0002070697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000345513,"about_ca_system_score_gemma":0.0002410537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005040118,"about_ca_topic_score_gemma":0.000466792,"domain_scores_codex":[0.9997957,0.00004034642,0.00002015916,0.00003050676,0.00006421003,0.00004898922],"domain_scores_gemma":[0.9998621,0.000007797115,0.00004875397,0.00001002511,0.00002150409,0.00004988924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001241774,0.0002420828,0.002874411,0.0002632226,0.0000635726,0.0006483885,0.00006125541,0.0001178931,0.9843859,0.0006591581,0.0002473651,0.009194948],"study_design_scores_gemma":[0.0001753516,0.002328552,0.1122764,0.00008341289,0.0003081848,0.00314757,0.0001733439,0.004098434,0.8641617,0.001107443,0.01211316,0.00002630487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717963,0.01305509,0.01078774,0.0003872702,0.0002442203,0.00008641627,0.0001902641,0.0002486754,0.003203936],"genre_scores_gemma":[0.9922103,0.003328498,0.001750916,0.0001605263,0.00004738318,0.00002722509,0.0001993663,0.00001120707,0.002264444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0015277,"threshold_uncertainty_score":0.005110681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0163391026169467,"score_gpt":0.3067695087805262,"score_spread":0.2904304061635795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}