{"id":"W2738560579","doi":"10.1177/1010428317717137","title":"HPV16 E6/E7 upregulates HIF-2α and VEGF by inhibiting LKB1 in lung cancer cells","year":2017,"lang":"en","type":"article","venue":"Tumor Biology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Vascular endothelial growth factor; Downregulation and upregulation; Cancer research; Vascular endothelial growth factor A; Lung cancer; Biology; Hypoxia-inducible factors; Carcinogenesis; Protein kinase A; Kinase; Cancer; Medicine; Cell biology; Internal medicine; Gene; VEGF receptors; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001220947,0.000133249,0.0001571912,0.00002760748,0.0001840965,0.00003769402,0.0002095472,0.0001160154,0.00004436268],"category_scores_gemma":[0.00003093784,0.0001217692,0.00003256771,0.00002593292,0.0002113582,0.000005461773,0.0001452966,0.00008455174,0.000003720467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001966201,"about_ca_system_score_gemma":0.00004666761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005355222,"about_ca_topic_score_gemma":0.0003027115,"domain_scores_codex":[0.9991146,0.00003878969,0.0001733517,0.0003767039,0.0000308879,0.0002656477],"domain_scores_gemma":[0.9994321,0.000008630236,0.000135651,0.0003340867,0.00003361164,0.00005593141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002181618,0.00001902564,0.03407226,0.00001539064,0.00001532851,0.00000200106,0.00002713684,0.000005629699,0.9588309,0.0001360383,0.002168963,0.00468555],"study_design_scores_gemma":[0.0008140188,0.00009873153,0.03927434,0.00003571714,0.00001555621,0.00001025859,0.00005096572,0.0002763707,0.9334742,0.0001915638,0.02545424,0.0003040221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917501,0.006371951,0.00005665994,0.0005062156,0.0001613868,0.000130483,0.00007311896,0.000007592459,0.0009424957],"genre_scores_gemma":[0.9976413,0.001037402,0.0001074318,0.0002206705,0.0001788729,0.00006165648,0.00006180535,0.00001563168,0.000675189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02535665,"threshold_uncertainty_score":0.4965603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007393524656837879,"score_gpt":0.2837283086039604,"score_spread":0.2763347839471225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}