{"id":"W2738667812","doi":"10.1038/s41598-017-06847-z","title":"DNA methylation signatures of chronic alcohol dependence in purified CD3+ T-cells of patients undergoing alcohol treatment","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Learning Partnership; BC Children's Hospital; Canadian Institute for Advanced Research; University of British Columbia","funders":"Canadian Institutes of Health Research; Eberhard Karls Universität Tübingen; Deutsche Forschungsgemeinschaft; National Alliance for Research on Schizophrenia and Depression; Schuler-Stiftung; Canadian Institute for Advanced Research","keywords":"dNaM; DNA methylation; Epigenome; CpG site; Epigenomics; Methylation; Alcohol; Alcohol dependence; Biology; Epigenetics; Genetics; Internal medicine; Bioinformatics; Medicine; DNA; Gene; Biochemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006495299,0.0001165044,0.0002174934,0.0003429536,0.000207458,0.0002356078,0.00008646459,0.0001894669,0.001640207],"category_scores_gemma":[0.0003107743,0.00008933374,0.00009750643,0.000297584,0.0001064851,0.00006761526,0.000148482,0.000190853,0.0002075286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000111565,"about_ca_system_score_gemma":0.00007699743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002010416,"about_ca_topic_score_gemma":0.001928671,"domain_scores_codex":[0.999929,0.0000114188,0.000005994008,0.00002303109,0.00001229693,0.00001830753],"domain_scores_gemma":[0.9998997,0.00001910921,0.00002639181,0.000009339302,0.00002170078,0.00002375948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001900991,0.00009898299,0.7503921,0.00004964184,0.00008155735,0.0003273852,0.000483739,0.0001204745,0.2332167,0.00003615856,0.0002110914,0.01308119],"study_design_scores_gemma":[0.00001171619,0.0002843721,0.9915956,0.000003457504,0.00003372504,0.0006243176,0.0002084203,0.0002205256,0.006622941,0.00004057513,0.0003502378,0.000004134552],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993722,0.0001352181,0.0001304151,0.00001089088,0.000001709198,0.000004129522,0.0001710555,0.000005186164,0.0001691155],"genre_scores_gemma":[0.9993802,0.00004379429,0.0001002793,0.0000171147,0.000002156858,0.000005578656,0.0002090535,0.00000271909,0.0002390778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002010416,"threshold_uncertainty_score":0.005487025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02114667165847955,"score_gpt":0.2891207908564498,"score_spread":0.2679741191979703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}