{"id":"W2738714440","doi":"10.1016/j.jaci.2017.06.027","title":"Toll-like receptor 3 blockade in rhinovirus-induced experimental asthma exacerbations: A randomized controlled study","year":2017,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University; University of Calgary","funders":"Janssen Research and Development; National Institute for Health and Care Research","keywords":"Rhinovirus; Medicine; Placebo; Asthma; Respiratory system; Internal medicine; Clinical endpoint; Immunology; Lung function; Randomized controlled trial; Gastroenterology; Lung; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002396987,0.001798842,0.007801086,0.0005365537,0.0007519173,0.001427426,0.001252366,0.002475194,0.005316241],"category_scores_gemma":[0.00202799,0.0009330533,0.003735516,0.0006911195,0.002043595,0.001493874,0.0006063574,0.003247748,0.0007447869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008935648,"about_ca_system_score_gemma":0.001187347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001245659,"about_ca_topic_score_gemma":0.002034976,"domain_scores_codex":[0.9985757,0.0006463291,0.0001471166,0.0002459281,0.0001278606,0.0002571211],"domain_scores_gemma":[0.9986178,0.0004482272,0.0003250707,0.0001710674,0.0001083325,0.0003295342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9889236,0.00270345,0.0003077984,0.0006371754,0.001388947,0.00002201052,0.00001481082,0.00008901656,0.001048373,0.00003680049,0.0001370589,0.004690915],"study_design_scores_gemma":[0.9658663,0.0309007,0.001229962,0.0000454752,0.001355661,0.00001328127,0.00001637713,0.000150441,0.000162214,0.00005743196,0.0001900997,0.00001190098],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779575,0.01433457,0.001039223,0.0005879474,0.001065979,0.003079731,0.0006113332,0.000108603,0.001215058],"genre_scores_gemma":[0.9853555,0.00616727,0.001275348,0.001041578,0.0009407107,0.003023473,0.0005760958,0.00002450574,0.001595486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007801086,"threshold_uncertainty_score":0.01778454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03128341119211031,"score_gpt":0.3677231095926696,"score_spread":0.3364396984005593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}