{"id":"W2738925124","doi":"10.3389/fimmu.2017.00832","title":"Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections?","year":2017,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":242,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Human leukocyte antigen; Immunology; Immune system; Major histocompatibility complex; Biology; Viral pathogenesis; Context (archaeology); Allele; Hepatitis C virus; Pathogenesis; Virology; Virus; Antigen; Genetics; Viral replication; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004263383,0.0005409221,0.0008797823,0.001116431,0.000218915,0.001009515,0.0005684049,0.0009627963,0.002149313],"category_scores_gemma":[0.0005230012,0.0001554054,0.0002330014,0.001363857,0.0005680889,0.00157071,0.0006166506,0.001374317,0.00141501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004886839,"about_ca_system_score_gemma":0.0008563049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005312638,"about_ca_topic_score_gemma":0.0006912331,"domain_scores_codex":[0.9998757,0.00002701656,0.00001656066,0.00002389224,0.00003825528,0.00001860146],"domain_scores_gemma":[0.9998034,0.00008257432,0.00002703615,0.000006159711,0.00005161562,0.00002930926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007342706,0.00004310762,0.0003276971,0.008187745,0.00005300912,0.0001845914,0.0001078625,0.0001930185,0.00304407,0.00601702,0.02396742,0.9578011],"study_design_scores_gemma":[0.0000073473,0.00008789104,0.001410439,0.002316642,0.00005698881,0.001492,0.0001470527,0.00006310312,0.0005967533,0.003771745,0.9900326,0.00001757468],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001254689,0.9985582,0.00009953587,0.0003798038,0.0002290776,0.000001269251,0.000006596154,0.000003771571,0.0005962657],"genre_scores_gemma":[0.0009261571,0.9978874,0.0001078266,0.0002362588,0.0002861328,0.000003304531,0.00001545282,0.000001192679,0.0005362398],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002149313,"threshold_uncertainty_score":0.007190168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02511325607136784,"score_gpt":0.2925498931833921,"score_spread":0.2674366371120243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}