{"id":"W2738956768","doi":"10.3791/56075","title":"Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling","year":2017,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Shanghai General Hospital; Crohn's and Colitis Foundation of Canada; Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning; Crohn's and Colitis Foundation","keywords":"Reporter gene; Luciferase; Cell biology; Toll-like receptor; Biology; Immune system; Signal transduction; Cell culture; Innate immune system; Transfection; Chemistry; Gene expression; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008128426,0.0001478951,0.0004883164,0.0002365475,0.0002166781,0.00003381158,0.000296035,0.0001478606,0.00008915862],"category_scores_gemma":[0.0001897939,0.0001285639,0.000210879,0.00005124667,0.0001366251,0.0004457093,0.00006508209,0.000155697,0.00001237026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007296023,"about_ca_system_score_gemma":0.00008332355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000471717,"about_ca_topic_score_gemma":6.699328e-7,"domain_scores_codex":[0.9984025,0.0002090299,0.0009370235,0.0001213613,0.00007606739,0.0002540344],"domain_scores_gemma":[0.9980363,0.0001635057,0.001414241,0.0002060432,0.0001580959,0.00002184329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003894736,0.0002161056,0.000275757,0.00001810846,0.0002400751,0.000003640369,0.002002741,0.00001495008,0.9910085,0.00003537447,0.0001768475,0.002113128],"study_design_scores_gemma":[0.006608617,0.00057201,0.0004760075,0.0003323464,0.0000383213,0.00001271213,0.001689203,0.00001798539,0.9883274,0.00002562224,0.001775504,0.0001242518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950054,0.00306527,0.0004655761,0.00006251177,0.001107609,0.0002539581,0.000004567464,0.00000555237,0.00002955988],"genre_scores_gemma":[0.998284,0.00008102828,0.001351975,0.00001580794,0.00004725289,0.00001219403,0.000005788671,0.00001694409,0.0001850101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003278603,"threshold_uncertainty_score":0.5242685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03298586892181014,"score_gpt":0.3878558475715326,"score_spread":0.3548699786497225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}