{"id":"W2739019370","doi":"10.1016/s0140-6736(17)31963-3","title":"Recombinant human C1 esterase inhibitor for prophylaxis of hereditary angio-oedema: a phase 2, multicentre, randomised, double-blind, placebo-controlled crossover trial","year":2017,"lang":"en","type":"article","venue":"The Lancet","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Ottawa Allergy Research Corporation","funders":"","keywords":"Placebo; Medicine; Crossover study; Clinical endpoint; Internal medicine; Recombinant DNA; Clinical trial; Adverse effect; Double blind; Randomization; Pharmacology; Pathology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002485957,0.002818692,0.005841431,0.0005787875,0.000620503,0.001447102,0.001213495,0.003169064,0.009266919],"category_scores_gemma":[0.002448469,0.001066587,0.002065227,0.0006528837,0.001542992,0.001597193,0.0004741494,0.003290219,0.00138744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009492895,"about_ca_system_score_gemma":0.001218634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00167747,"about_ca_topic_score_gemma":0.002556312,"domain_scores_codex":[0.9990855,0.0004076289,0.00005613716,0.0002200271,0.00006942038,0.0001612893],"domain_scores_gemma":[0.9990547,0.000347651,0.0001670351,0.00008563118,0.00006847366,0.0002763892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.990513,0.002072632,0.0001353921,0.0006125514,0.0007107409,0.00003200308,0.00003358423,0.0001026281,0.001520222,0.00007990647,0.0004632352,0.003724094],"study_design_scores_gemma":[0.9880649,0.01106064,0.0003094077,0.00001302024,0.0001759032,0.00001313567,0.000006945419,0.00007583026,0.00007488316,0.00004711737,0.0001521432,0.000005970675],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657131,0.0159234,0.002389165,0.001411579,0.002153254,0.007371278,0.00206005,0.0003371417,0.002641016],"genre_scores_gemma":[0.9669531,0.008802847,0.003484111,0.002245009,0.001186993,0.009026851,0.001561473,0.00007652583,0.006663108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009266919,"threshold_uncertainty_score":0.03100091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08068712317786413,"score_gpt":0.3762369895693388,"score_spread":0.2955498663914747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}