{"id":"W2739019370","doi":"10.1016/s0140-6736(17)31963-3","title":"Recombinant human C1 esterase inhibitor for prophylaxis of hereditary angio-oedema: a phase 2, multicentre, randomised, double-blind, placebo-controlled crossover trial","year":2017,"lang":"en","type":"article","venue":"The Lancet","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Ottawa Allergy Research Corporation","funders":"","keywords":"Placebo; Medicine; Crossover study; Clinical endpoint; Internal medicine; Recombinant DNA; Clinical trial; Adverse effect; Double blind; Randomization; Pharmacology; Pathology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001159739,0.0003070272,0.001539686,0.00007916291,0.0006714798,0.000140065,0.0004233324,0.0001655141,0.0001132426],"category_scores_gemma":[0.0007042432,0.0001922586,0.0005998389,0.0000640242,0.0002591223,0.0002166958,0.00008280775,0.0001936791,0.00001077001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004723352,"about_ca_system_score_gemma":0.0001364252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000188063,"about_ca_topic_score_gemma":0.00008233881,"domain_scores_codex":[0.9978613,0.00009400941,0.0008233523,0.0003755799,0.0003483319,0.0004974188],"domain_scores_gemma":[0.9971531,0.0004907007,0.000774775,0.001220343,0.0002058987,0.0001551995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9832783,0.00103053,0.0007379784,0.00020376,0.0004003561,0.00002548069,0.0007335954,0.000007482485,0.001692544,0.0002440041,0.009468314,0.002177592],"study_design_scores_gemma":[0.9871412,0.001789858,0.0005271026,0.000241824,0.000568661,0.00001403361,0.00007726871,0.0009608957,0.005528596,0.0003286277,0.002592491,0.000229437],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985406,0.0007649228,0.00008249521,0.001901311,0.0016436,0.009264427,0.00008511954,0.00006784951,0.0007842988],"genre_scores_gemma":[0.9902529,0.00003270303,0.0002879669,0.0001832475,0.005102424,0.0007113707,0.00009848407,0.00004773046,0.003283193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008553057,"threshold_uncertainty_score":0.7840077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08068712317786413,"score_gpt":0.3762369895693388,"score_spread":0.2955498663914747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}