{"id":"W2739044551","doi":"10.1002/jbmr.3200","title":"Bone Strength Estimated by Micro-Finite Element Analysis (µFEA) Is Heritable and Shares Genetic Predisposition With Areal BMD: The Framingham Study","year":2017,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Bone health and osteoporosis research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Quantitative computed tomography; Bone mineral; Framingham Heart Study; Tibia; Heritability; Medicine; Bone density; Femoral neck; Osteopenia; Densitometry; Internal medicine; Osteoporosis; Surgery; Biology; Framingham Risk Score; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003131205,0.0003756199,0.0003893761,0.000705382,0.0002923894,0.000407242,0.0003899344,0.0004459617,0.001149087],"category_scores_gemma":[0.004652722,0.0003013889,0.0005062671,0.000616737,0.0004569007,0.0002555577,0.0003973494,0.0004995295,0.0001365702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001332235,"about_ca_system_score_gemma":0.0001452742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004071172,"about_ca_topic_score_gemma":0.002653336,"domain_scores_codex":[0.9989784,0.0004988783,0.00009484583,0.0002024487,0.0001709331,0.00005460596],"domain_scores_gemma":[0.9975569,0.0008613335,0.0007182573,0.0005730237,0.0001619182,0.00012851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001980939,0.00001933401,0.9958046,0.00001280207,0.0004646904,0.00009636592,0.0001324742,0.0001428638,0.0008596291,0.00008050592,0.000102713,0.002085885],"study_design_scores_gemma":[0.000006516893,0.00004782637,0.9988828,0.000005127252,0.0001054701,0.0001675763,0.00004054546,0.0004859667,0.0000954748,0.00007351502,0.00008505174,0.000004048516],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981408,0.0003317266,0.001010348,0.00004921482,0.000008495312,0.000005276187,0.0001812266,0.000008143475,0.0002648529],"genre_scores_gemma":[0.9995226,0.00005667112,0.0002354055,0.00001051499,0.00001314265,0.000004830865,0.00007038208,0.000002236409,0.00008436423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004071172,"threshold_uncertainty_score":0.0165596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05598065276101621,"score_gpt":0.4000277319503968,"score_spread":0.3440470791893805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}