{"id":"W2739066978","doi":"10.1210/en.2017-00159","title":"MEF2C Interacts With c-FOS in PTH-Stimulated Mmp13 Gene Expression in Osteoblastic Cells","year":2017,"lang":"en","type":"article","venue":"Endocrinology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; York University","keywords":"MEF2C; Chromatin immunoprecipitation; Transcription factor; AP-1 transcription factor; HDAC4; JUNB; RUNX2; Parathyroid hormone; Promoter; Gene knockdown; Molecular biology; Chemistry; Gene expression; Enhancer; HDAC8; Biology; Internal medicine; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002221735,0.000386718,0.0003760997,0.0003804744,0.0004073449,0.0003034362,0.0002982233,0.0003896873,0.003026407],"category_scores_gemma":[0.0002307913,0.0002482199,0.0005033387,0.0002708849,0.0002434765,0.000201284,0.0004220922,0.0005473982,0.0009996236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005770934,"about_ca_system_score_gemma":0.0002763694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001842287,"about_ca_topic_score_gemma":0.002768027,"domain_scores_codex":[0.9996481,0.00003629563,0.00002683151,0.00009744621,0.0001189405,0.00007247549],"domain_scores_gemma":[0.9998537,0.00002683709,0.00002955102,0.00001761572,0.00003391329,0.00003825244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001046108,0.00002117526,0.0002868387,0.00006163031,0.000006531586,0.00006428063,0.00001943067,0.00002063886,0.9985678,0.00005611011,0.00009482566,0.000696122],"study_design_scores_gemma":[0.00006145996,0.0001344541,0.04471982,0.00003904182,0.00002786614,0.0005493362,0.00007553132,0.001956474,0.9417685,0.00007654251,0.010574,0.00001703797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758446,0.01026052,0.00656805,0.0003782854,0.0002059703,0.00005710057,0.002195513,0.0001373861,0.004352465],"genre_scores_gemma":[0.9754583,0.002071665,0.004521494,0.0003225279,0.00005590223,0.0001840292,0.004442649,0.00005844513,0.01288493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003026407,"threshold_uncertainty_score":0.01012433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01276151932819918,"score_gpt":0.2890088574456027,"score_spread":0.2762473381174035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}