{"id":"W2739132596","doi":"10.1139/cjc-2017-0168","title":"An affinity-based probe for methyltransferase enzymes based on sinefungin","year":2017,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bioorthogonal chemistry; Chemistry; Methyltransferase; Biochemistry; Enzyme; Epigenetics; Methylation; Click chemistry; Protein methylation; Combinatorial chemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002454395,0.000238238,0.000287287,0.00004102391,0.0006182886,0.0002933893,0.001001342,0.000230854,0.001415763],"category_scores_gemma":[0.000482929,0.0002468764,0.0002540298,0.0000444484,0.0001832709,0.0001537224,0.000004264026,0.0004179044,0.00000332462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001601959,"about_ca_system_score_gemma":0.002116485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001691891,"about_ca_topic_score_gemma":0.0003661502,"domain_scores_codex":[0.9987763,0.000007241839,0.0003894703,0.0002595307,0.0001832342,0.0003841906],"domain_scores_gemma":[0.9971676,0.0001754071,0.0003679202,0.0009679021,0.0002704882,0.001050627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001119352,0.0001565302,0.001055725,0.0003628546,0.00004137776,0.00006405878,0.00003910194,0.0006652824,0.994347,0.00005323686,0.001758383,0.001344554],"study_design_scores_gemma":[0.001431406,0.00003305111,0.00006600074,0.0001870737,0.00006435044,0.00002030541,0.000069564,0.0009415786,0.9722468,0.0002152787,0.02445976,0.0002648287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650045,0.0001670026,0.004739209,0.006022771,0.0001251133,0.0001660545,0.001042668,0.00004290521,0.0226898],"genre_scores_gemma":[0.9970149,0.000001633791,0.001437355,0.0002816774,0.0006248103,0.00003315935,0.0001171878,0.00003920012,0.0004500495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03201045,"threshold_uncertainty_score":0.9999983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02382573399048863,"score_gpt":0.2767109030794494,"score_spread":0.2528851690889607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}