{"id":"W2739165387","doi":"10.1128/msphere.00158-17","title":"Evolution of Cost-Free Resistance under Fluctuating Drug Selection in Pseudomonas aeruginosa","year":2017,"lang":"en","type":"article","venue":"mSphere","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; Ontario Genomics; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Antibiotics; Pseudomonas aeruginosa; Antibiotic resistance; Biology; Experimental evolution; Ciprofloxacin; Drug resistance; Microbiology; Genetics; Bacteria; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003626126,0.0001849293,0.0002722506,0.0001858566,0.0002427158,0.0004874158,0.0003313898,0.0004036479,0.0005907965],"category_scores_gemma":[0.001135309,0.0001397751,0.0001405793,0.0001987889,0.0004531853,0.0003109987,0.0004436659,0.0005424845,0.0000932476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005467818,"about_ca_system_score_gemma":0.0002723275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008007545,"about_ca_topic_score_gemma":0.001064666,"domain_scores_codex":[0.9997351,0.0001097251,0.00001600648,0.00003995914,0.00006222176,0.0000370564],"domain_scores_gemma":[0.9994872,0.0002137718,0.0001124519,0.00007289634,0.00004659328,0.00006711287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000162561,0.00007265491,0.003794192,0.00003222637,0.00001352745,0.0001086081,0.00007229474,0.002478328,0.9883435,0.0007758187,0.00002781149,0.004118437],"study_design_scores_gemma":[0.0002556351,0.004100384,0.1472872,0.00004927857,0.0001071367,0.001468846,0.0009979452,0.168124,0.6673613,0.006238607,0.003842419,0.0001673321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989805,0.00005473397,0.0006984526,0.00004244836,0.000002515021,0.000003111243,0.0000140127,0.000005897596,0.0001983357],"genre_scores_gemma":[0.9988266,0.00007995877,0.0008703228,0.00002458889,0.000002116571,0.00001093505,0.00002364677,0.000006352654,0.0001554671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008007545,"threshold_uncertainty_score":0.003967226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007612953332857272,"score_gpt":0.2540677615057041,"score_spread":0.2464548081728468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}