{"id":"W2739277515","doi":"10.1016/j.ejphar.2017.07.034","title":"Bidirectional allosteric interactions between cannabinoid receptor 1 (CB 1 ) and dopamine receptor 2 long (D 2L ) heterotetramers","year":2017,"lang":"en","type":"article","venue":"European Journal of Pharmacology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Dalhousie University","funders":"Dalhousie University","keywords":"Cannabinoid receptor; Chemistry; Agonist; Allosteric regulation; Cannabinoid; Quinpirole; Receptor; Dopamine receptor D2; G protein-coupled receptor; Homomeric; Adenosine A2A receptor; Endogenous agonist; Inverse agonist; Pharmacology; Biochemistry; Dopamine receptor D1; Biology; Protein subunit; Adenosine receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002595096,0.0002254972,0.000384135,0.0001069856,0.0003796929,0.0005872743,0.0006354217,0.00035253,0.00531871],"category_scores_gemma":[0.0003677136,0.0002101623,0.0002104759,0.0001144169,0.0002716864,0.0004130963,0.0004085809,0.0005545975,0.0009110768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005301216,"about_ca_system_score_gemma":0.0001816791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003332022,"about_ca_topic_score_gemma":0.001104839,"domain_scores_codex":[0.9997645,0.00006451099,0.00001059908,0.0000553663,0.00004141535,0.0000636693],"domain_scores_gemma":[0.9998823,0.00005097342,0.00002084676,0.00001472662,0.00000875422,0.00002236804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007991653,0.000146957,0.0004154412,0.0001422239,0.00003399057,0.0002740951,0.0001733824,0.001290533,0.977803,0.009828208,0.001506205,0.007586794],"study_design_scores_gemma":[0.0002988178,0.0008781497,0.001735403,0.00004289008,0.00008693997,0.0008252482,0.0004076077,0.0461897,0.9267856,0.003995314,0.01865963,0.00009463182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789322,0.001108924,0.00976335,0.0005344548,0.0002499309,0.0000483046,0.0001147188,0.0002382718,0.009009714],"genre_scores_gemma":[0.9941011,0.0002964115,0.002255814,0.0003003173,0.00002158485,0.00003939918,0.00007230327,0.0000340716,0.002878973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00531871,"threshold_uncertainty_score":0.01779282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03555287606119078,"score_gpt":0.3519230962067065,"score_spread":0.3163702201455157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}