{"id":"W2739277515","doi":"10.1016/j.ejphar.2017.07.034","title":"Bidirectional allosteric interactions between cannabinoid receptor 1 (CB 1 ) and dopamine receptor 2 long (D 2L ) heterotetramers","year":2017,"lang":"en","type":"article","venue":"European Journal of Pharmacology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Dalhousie University","funders":"Dalhousie University","keywords":"Cannabinoid receptor; Chemistry; Agonist; Allosteric regulation; Cannabinoid; Quinpirole; Receptor; Dopamine receptor D2; G protein-coupled receptor; Homomeric; Adenosine A2A receptor; Endogenous agonist; Inverse agonist; Pharmacology; Biochemistry; Dopamine receptor D1; Biology; Protein subunit; Adenosine receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009840889,0.0002000236,0.0004352701,0.0003361992,0.000391258,0.0001095309,0.0003282735,0.00003934517,0.00231857],"category_scores_gemma":[0.0002355211,0.0001695744,0.0001879834,0.00009342952,0.0003948826,0.0002873158,0.0001893763,0.0009051483,0.0001078367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001569844,"about_ca_system_score_gemma":0.0001790694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002218199,"about_ca_topic_score_gemma":0.000004995144,"domain_scores_codex":[0.9980125,0.0004613763,0.0005730631,0.0002510296,0.000334129,0.00036783],"domain_scores_gemma":[0.9982704,0.00003613732,0.0005758129,0.0002087509,0.0004313514,0.0004775453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001034296,0.0002390055,0.05190174,0.00009260792,0.0006200537,0.0008051494,0.0002126273,0.000004318936,0.4069306,0.000002847126,0.4727395,0.0654173],"study_design_scores_gemma":[0.003265173,0.0015063,0.3438855,0.00009212893,0.0002248721,0.001324673,0.00007569567,0.00001328906,0.01582741,0.000001651337,0.6336072,0.0001761326],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9594533,0.0004528592,0.0001003016,0.03458578,0.002477823,0.000217856,0.00003103384,0.00001876817,0.002662264],"genre_scores_gemma":[0.9809045,0.0004635639,0.000392965,0.0005623038,0.003592212,0.000005051178,0.00001269577,0.00005708589,0.01400968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3911031,"threshold_uncertainty_score":0.9985934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03555287606119078,"score_gpt":0.3519230962067065,"score_spread":0.3163702201455157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}