{"id":"W2739400913","doi":"10.1200/jco.2016.34.15_suppl.tps11072","title":"The Selinexor in Advanced Liposarcoma (SEAL) study: A phase 2/3, multicenter, randomized, double blind study of selinexor versus placebo in patients with advanced, unresectable, dedifferentiated liposarcoma (DDLS).","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Clinical endpoint; Placebo; Internal medicine; Phases of clinical research; Oncology; Gastroenterology; Randomized controlled trial; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001839725,0.001763716,0.002287347,0.0005031073,0.000356347,0.0006894197,0.0007618766,0.001420391,0.00430706],"category_scores_gemma":[0.0008456627,0.0006756075,0.001318188,0.0003098235,0.001282652,0.001037781,0.000388995,0.002311079,0.0007678304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004084527,"about_ca_system_score_gemma":0.001013333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003722647,"about_ca_topic_score_gemma":0.0009385778,"domain_scores_codex":[0.9996365,0.0001957479,0.00002189085,0.00006150071,0.00002915551,0.00005504534],"domain_scores_gemma":[0.9994199,0.0001227815,0.0001569652,0.00004296156,0.00003467916,0.000222832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9335202,0.02328317,0.001707498,0.0008168633,0.0007122496,0.00009167589,0.0001137441,0.0006943457,0.01612756,0.0001737115,0.0008757904,0.02188317],"study_design_scores_gemma":[0.8464694,0.1494153,0.001901892,0.00001921824,0.0002431336,0.00005692499,0.00002370194,0.0003256231,0.0009510087,0.00009848963,0.0004834092,0.00001199726],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911718,0.002025472,0.0006504516,0.0004175797,0.0001692687,0.003940722,0.000689609,0.0001172614,0.0008178921],"genre_scores_gemma":[0.9848652,0.002200732,0.002042889,0.001023926,0.0003070426,0.005950021,0.001016221,0.00002401654,0.002570036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00430706,"threshold_uncertainty_score":0.01440853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08717057022810526,"score_gpt":0.4517596671861356,"score_spread":0.3645890969580303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}