{"id":"W2739401537","doi":"10.2147/ceg.s121841","title":"Children’s International Polyposis (CHIP) study: a randomized, double-blind, placebo-controlled study of celecoxib in children with familial adenomatous polyposis","year":2017,"lang":"en","type":"article","venue":"Clinical and Experimental Gastroenterology","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Global Affairs Canada","funders":"Cliniques Universitaires Saint-Luc; Chinese University of Hong Kong; Universitair Ziekenhuis Gent; Rush University; Cincinnati Children's Hospital Medical Center; Memorial Sloan-Kettering Cancer Center; Cleveland Clinic; Vanderbilt University; Queen Mary University of London; University of Nebraska Medical Center; Vanderbilt University Medical Center; Pfizer","keywords":"Medicine; Celecoxib; Placebo; Familial adenomatous polyposis; Colorectal cancer; Internal medicine; Gastroenterology; Adverse effect; Randomization; Randomized controlled trial; Malignancy; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001137126,0.0004063986,0.00217933,0.0002429781,0.0001787901,0.00005291816,0.0003924352,0.0001785623,0.0000541174],"category_scores_gemma":[0.0001470989,0.0002880508,0.0003031717,0.00004344359,0.0007535808,0.0001264282,0.0003245147,0.0004792757,0.000009272252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003848643,"about_ca_system_score_gemma":0.00004223831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001005151,"about_ca_topic_score_gemma":0.0005322442,"domain_scores_codex":[0.9965068,0.0005814856,0.00134726,0.000714879,0.0003858077,0.0004638085],"domain_scores_gemma":[0.9982092,0.0001738739,0.0006449671,0.0006170712,0.00006165526,0.0002932035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4597492,0.005357062,0.5328146,0.000003518793,0.001242124,0.00002508939,0.000557616,0.000002006937,0.0001435163,0.000002144308,0.00001266351,0.00009052045],"study_design_scores_gemma":[0.5161682,0.00685891,0.4759063,0.00002726368,0.0003250539,0.000100434,0.0002940614,0.00003543514,0.0001867794,0.000001261719,7.117426e-7,0.00009562074],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992558,0.0001296728,0.000005636775,0.0001864668,0.0005376218,0.006460015,0.00000965946,0.00003127021,0.00008166634],"genre_scores_gemma":[0.9983429,0.00002969146,0.00007085106,0.000207456,0.0005168223,0.0007152743,0.0000257464,0.00003772652,0.00005355602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05690826,"threshold_uncertainty_score":0.9999571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02712597195127716,"score_gpt":0.3448648757882689,"score_spread":0.3177389038369917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}