{"id":"W2739418644","doi":"10.1002/mus.25752","title":"Osteopontin is linked with AKT, FoxO1, and myostatin in skeletal muscle cells","year":2017,"lang":"en","type":"article","venue":"Muscle & Nerve","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"AGADA Biosciences","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Neurological Disorders and Stroke; National Institutes of Health; Muscular Dystrophy Association","keywords":"Myostatin; Duchenne muscular dystrophy; Osteopontin; Endocrinology; Internal medicine; Muscle hypertrophy; FOXO1; Skeletal muscle; Protein kinase B; Muscular dystrophy; mdx mouse; Biology; Phosphorylation; Chemistry; Medicine; Dystrophin; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001405617,0.0002592596,0.0001600656,0.00018588,0.0002075688,0.000202461,0.0001370003,0.000196582,0.001878839],"category_scores_gemma":[0.00008941863,0.0001510391,0.0001916203,0.0001505142,0.0002792605,0.0001772038,0.0002554863,0.0002986752,0.0002794405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003440323,"about_ca_system_score_gemma":0.0002059453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006657867,"about_ca_topic_score_gemma":0.0009172772,"domain_scores_codex":[0.9999101,0.00001015231,0.000007045823,0.00002762408,0.00002800945,0.0000170457],"domain_scores_gemma":[0.999911,0.00000661825,0.00004543478,0.000005900314,0.000008468972,0.00002265844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003048308,0.00003670408,0.003282055,0.00008958378,0.00001403283,0.0001782089,0.00002962042,0.00005034361,0.9934878,0.0001879748,0.0001181999,0.00222066],"study_design_scores_gemma":[0.0001347864,0.0008435662,0.3011661,0.00005371078,0.0001185404,0.002631176,0.0001832373,0.001865469,0.6828572,0.000545888,0.00958459,0.00001580547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937779,0.003674876,0.0009733163,0.0001199868,0.0000331289,0.00001045642,0.0002000457,0.0000279292,0.001182299],"genre_scores_gemma":[0.9935266,0.001755422,0.000801267,0.00006269284,0.00001417395,0.00002365127,0.000449057,0.00000617421,0.003360951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001878839,"threshold_uncertainty_score":0.00628531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008522656222888723,"score_gpt":0.2392949331819149,"score_spread":0.2307722769590261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}