{"id":"W2739418644","doi":"10.1002/mus.25752","title":"Osteopontin is linked with AKT, FoxO1, and myostatin in skeletal muscle cells","year":2017,"lang":"en","type":"article","venue":"Muscle & Nerve","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"AGADA Biosciences","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Neurological Disorders and Stroke; National Institutes of Health; Muscular Dystrophy Association","keywords":"Myostatin; Duchenne muscular dystrophy; Osteopontin; Endocrinology; Internal medicine; Muscle hypertrophy; FOXO1; Skeletal muscle; Protein kinase B; Muscular dystrophy; mdx mouse; Biology; Phosphorylation; Chemistry; Medicine; Dystrophin; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473654,0.0001974802,0.0001935197,0.00003721397,0.0002267453,0.00005854298,0.0002639322,0.0001808494,0.00005339492],"category_scores_gemma":[0.00004394551,0.0001776114,0.00006130939,0.00003677176,0.0002154326,0.00001392286,0.0001947475,0.0001442493,0.00001435614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005994455,"about_ca_system_score_gemma":0.00004561769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004281217,"about_ca_topic_score_gemma":0.0009668429,"domain_scores_codex":[0.9988617,0.00005949608,0.000174842,0.0004792258,0.00008869027,0.0003360669],"domain_scores_gemma":[0.9991001,0.00001571958,0.000129999,0.0006205245,0.00004049932,0.00009312714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002344366,0.0002120181,0.01086943,0.00006964639,0.00005517416,0.00004184705,0.0006875113,0.00002938117,0.9336408,0.0001210256,0.00292246,0.05111631],"study_design_scores_gemma":[0.00408469,0.001037427,0.8891162,0.00005421338,0.00003080681,0.000005303087,0.0005068051,0.0001550082,0.06181924,0.0005332811,0.04199966,0.000657321],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956302,0.0003154516,0.00004960917,0.0004769395,0.00009451876,0.0002064259,0.00002649134,0.00001150972,0.003188838],"genre_scores_gemma":[0.998379,0.00008130219,0.0003482654,0.0004999573,0.0001040397,0.00002866921,0.00004855761,0.00002630014,0.0004838882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8782468,"threshold_uncertainty_score":0.7242783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008522656222888723,"score_gpt":0.2392949331819149,"score_spread":0.2307722769590261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}