{"id":"W2739703387","doi":"10.1158/1538-7445.am2017-289","title":"Abstract 289: The key role of Mitostatin in the maintenance of genome stability","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"","keywords":"Spindle checkpoint; Mad2; Cell biology; Centrosome; Mitosis; Biology; Nocodazole; Anaphase; Chromosome instability; Mitotic exit; Anaphase-promoting complex; Chromosome segregation; Genome instability; Multipolar spindles; Spindle apparatus; Mitotic catastrophe; Cell cycle checkpoint; G2-M DNA damage checkpoint; PLK1; Cell cycle; Genetics; Chromosome; Cell division; DNA damage; Cancer; Cell; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003305768,0.0002323279,0.0001906759,0.0001175761,0.0001409897,0.0002499977,0.0001340836,0.0002086406,0.002515153],"category_scores_gemma":[0.00006816322,0.00006001261,0.000147925,0.0001136545,0.0001180245,0.0001689191,0.000201901,0.0003283084,0.0005776334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001705489,"about_ca_system_score_gemma":0.000125623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002359045,"about_ca_topic_score_gemma":0.000238102,"domain_scores_codex":[0.9999532,0.000005204255,0.000004478568,0.00000837224,0.00001416794,0.00001457024],"domain_scores_gemma":[0.9999293,0.00001114476,0.00001895939,0.000008442016,0.000006680701,0.00002549261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000108641,0.000005909804,0.0001115088,0.00003313578,0.000002439762,0.0001260661,0.000003240795,0.00001410686,0.9983768,0.0001100989,0.0000691703,0.001038869],"study_design_scores_gemma":[0.00001652798,0.0002721382,0.006481658,0.000006977429,0.00001408833,0.000930402,0.00001724027,0.0001950968,0.983098,0.00006811901,0.00889713,0.000002672597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792516,0.008858936,0.003314601,0.0003704059,0.000163861,0.00003902309,0.001797084,0.0001783323,0.006026127],"genre_scores_gemma":[0.9894344,0.002392033,0.001490011,0.00007045427,0.00005047207,0.00002333461,0.001537784,0.00002061366,0.004980956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002515153,"threshold_uncertainty_score":0.00841409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04540620729255348,"score_gpt":0.3647144532904397,"score_spread":0.3193082459978863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}