{"id":"W2739747835","doi":"10.1093/neuonc/nox142","title":"Divergent evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular vesicles and coupled with radiosensitization","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Temozolomide; Extracellular vesicles; Glioblastoma; Cancer research; Microvesicles; Stem cell; Extracellular; Vesicle; Resistance (ecology); Radiation tolerance; Chemistry; Biology; Cell biology; Medicine; Radiation therapy; Internal medicine; Gene; Biochemistry; microRNA; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008082593,0.0001287909,0.0001407939,0.0001780007,0.00008061095,0.0002877514,0.00006280338,0.000119811,0.0003203487],"category_scores_gemma":[0.0000912744,0.0000630229,0.0001587267,0.0001145143,0.0001255655,0.0001346875,0.0001886785,0.0001801731,0.00009671118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001631819,"about_ca_system_score_gemma":0.00009836553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003011511,"about_ca_topic_score_gemma":0.0003565447,"domain_scores_codex":[0.9999464,0.00000615816,0.000006465611,0.00001178905,0.00001775788,0.00001149233],"domain_scores_gemma":[0.9999284,0.000009175781,0.00002524104,0.000007688956,0.00001559101,0.00001393342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009411159,0.000005751886,0.002020115,0.00001629192,0.000005583198,0.00004321351,0.00003569104,0.00007313756,0.9967981,0.00007563132,0.000009688159,0.0008228007],"study_design_scores_gemma":[0.000006866359,0.0003706196,0.0677254,0.000006218995,0.00002932899,0.0005106055,0.0001423448,0.001072777,0.9285655,0.0000888948,0.001474072,0.000007340615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986093,0.0002809293,0.0006938368,0.00001054465,0.0000021842,0.000007328041,0.0001656503,0.00001071644,0.0002195416],"genre_scores_gemma":[0.9987338,0.0001601129,0.0004566966,0.000007923643,0.000001041094,0.000009739743,0.0002952996,0.000004660887,0.0003307612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003203487,"threshold_uncertainty_score":0.001183987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01560116601968802,"score_gpt":0.2664914305790017,"score_spread":0.2508902645593137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}