{"id":"W2739763269","doi":"10.1158/1078-0432.ccr-16-2882","title":"Pediatric Phase I Trial and Pharmacokinetic Study of Trebananib in Relapsed Solid Tumors, Including Primary Tumors of the Central Nervous System ADVL1115: A Children's Oncology Group Phase I Consortium Report","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute","keywords":"Medicine; Pharmacokinetics; Neutropenia; Anemia; Internal medicine; Toxicity; Gastroenterology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001348913,0.001096169,0.001276442,0.0002480453,0.0002830577,0.0004808501,0.0005181269,0.000581915,0.001465998],"category_scores_gemma":[0.000649749,0.000371922,0.0006640235,0.0003731448,0.000529846,0.0003690307,0.0001966833,0.002438899,0.0004088111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001088326,"about_ca_system_score_gemma":0.002189197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00156285,"about_ca_topic_score_gemma":0.00320899,"domain_scores_codex":[0.9995832,0.0001881205,0.00002380405,0.00007097182,0.00006534939,0.00006862457],"domain_scores_gemma":[0.9990065,0.0001665484,0.0002214231,0.0001058421,0.00009829592,0.0004015715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3790701,0.08326691,0.05524916,0.00121175,0.002143264,0.001841056,0.0008202892,0.009879934,0.2424753,0.0007919693,0.01735684,0.2058934],"study_design_scores_gemma":[0.2744405,0.5993386,0.07448741,0.00006995579,0.0008026776,0.003052694,0.0001177061,0.004944156,0.03247348,0.0002821678,0.009942444,0.00004825792],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944364,0.001223483,0.0009746047,0.0002277051,0.00003382663,0.001071127,0.001119896,0.00007484468,0.000838245],"genre_scores_gemma":[0.9875525,0.001697243,0.003476876,0.0004053485,0.00009269395,0.001628226,0.003741836,0.00004901979,0.001356276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00156285,"threshold_uncertainty_score":0.007896364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1884804343358965,"score_gpt":0.5543462899047323,"score_spread":0.3658658555688358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}