{"id":"W2740017049","doi":"10.1021/acscentsci.7b00299","title":"The Sweat Metabolome of Screen-Positive Cystic Fibrosis Infants: Revealing Mechanisms beyond Impaired Chloride Transport","year":2017,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Trillium Foundation; Canada Foundation for Innovation; Cystic Fibrosis Canada; Genome Canada","keywords":"Metabolome; Cystic fibrosis; SWEAT; Newborn screening; Metabolomics; Medicine; Chemistry; Internal medicine; Biochemistry; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001509719,0.0001992443,0.000390417,0.00008196245,0.001486804,0.0001502215,0.001190002,0.00005393193,0.00002298539],"category_scores_gemma":[0.002514075,0.0001286796,0.0001242638,0.0004474327,0.002232097,0.000830822,0.0001935989,0.0002305522,0.000009351919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001464025,"about_ca_system_score_gemma":0.0004802127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005875852,"about_ca_topic_score_gemma":0.00007639483,"domain_scores_codex":[0.9964736,0.00003697125,0.0004149893,0.0004997901,0.001435662,0.00113899],"domain_scores_gemma":[0.9975896,0.0002982469,0.0002771534,0.0009975475,0.0003574107,0.0004799877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001010314,0.00007287441,0.01126853,0.00005934991,0.00005320441,0.00004415631,0.0003931001,0.00003049198,0.971561,0.007286887,0.00004295607,0.008177176],"study_design_scores_gemma":[0.0006825629,0.0003198587,0.4853439,0.000238312,0.00007548572,0.00002779104,0.0001715162,0.000332424,0.5103275,0.002120756,0.0002216354,0.0001382579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991901,0.000559014,0.003625518,0.00153724,0.0003902812,0.0007755529,0.0001351559,0.00004119983,0.001034994],"genre_scores_gemma":[0.9924729,0.0002762389,0.006849656,0.00007600129,0.00007863409,0.00001698771,0.00001042468,0.0000151541,0.0002039343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4740754,"threshold_uncertainty_score":0.9998131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01247056863297442,"score_gpt":0.2968706181752725,"score_spread":0.2844000495422981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}