{"id":"W2740017049","doi":"10.1021/acscentsci.7b00299","title":"The Sweat Metabolome of Screen-Positive Cystic Fibrosis Infants: Revealing Mechanisms beyond Impaired Chloride Transport","year":2017,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Trillium Foundation; Canada Foundation for Innovation; Cystic Fibrosis Canada; Genome Canada","keywords":"Metabolome; Cystic fibrosis; SWEAT; Newborn screening; Metabolomics; Medicine; Chemistry; Internal medicine; Biochemistry; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001509246,0.0003216769,0.0003258022,0.0005303798,0.0001236932,0.0003815095,0.0001113975,0.0003017439,0.0004571867],"category_scores_gemma":[0.0003291825,0.0001009474,0.0001665624,0.0003293272,0.0001913902,0.0001655571,0.0002490242,0.0001676318,0.0001022201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001020434,"about_ca_system_score_gemma":0.0001129025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005975597,"about_ca_topic_score_gemma":0.0008891204,"domain_scores_codex":[0.999877,0.00001919897,0.00000886306,0.00003822215,0.00003524825,0.00002147195],"domain_scores_gemma":[0.999896,0.00002765002,0.00003671378,0.000008269179,0.00001415173,0.00001715286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003844209,0.0000187565,0.05030366,0.00007666103,0.00006055915,0.0006321765,0.0001741435,0.00007751789,0.9405168,0.00003426752,0.00005214773,0.007668796],"study_design_scores_gemma":[0.0000112699,0.0006957072,0.7635114,0.00003368279,0.0001391862,0.004820526,0.0003892754,0.001480368,0.2273306,0.0001866895,0.001380005,0.00002130275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973606,0.0008520652,0.001164692,0.00003638844,0.000003946349,0.000011699,0.0003242942,0.00002376913,0.0002224089],"genre_scores_gemma":[0.9974018,0.0005080898,0.001488148,0.00006927014,0.000005137061,0.000009231783,0.0003120805,0.000008850703,0.0001973788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005975597,"threshold_uncertainty_score":0.001529455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01247056863297442,"score_gpt":0.2968706181752725,"score_spread":0.2844000495422981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}