{"id":"W2740043261","doi":"10.1158/1538-7445.am2017-220","title":"Abstract 220: Proteomic identification of therapeutics targets for Enzalutamide resistance in Castration Resistant Prostate Cancer","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Université Laval","funders":"","keywords":"Enzalutamide; Prostate cancer; Androgen receptor; Androgen deprivation therapy; Context (archaeology); Cancer research; Androgen; Testosterone (patch); Medicine; Cancer; Cancer cell; Internal medicine; Oncology; Biology; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001104093,0.0003276693,0.0003104577,0.0004613894,0.0002087218,0.0004075716,0.0001581336,0.000294694,0.001572028],"category_scores_gemma":[0.0001082303,0.0001357179,0.0003673466,0.0004282765,0.000112739,0.000187288,0.0001771317,0.0002858434,0.0005632245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002199949,"about_ca_system_score_gemma":0.0001622352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006533241,"about_ca_topic_score_gemma":0.0006989018,"domain_scores_codex":[0.9999126,0.000007998845,0.000007213479,0.00002449115,0.0000319522,0.0000156628],"domain_scores_gemma":[0.9999504,0.000006120911,0.00001271444,0.000004256645,0.00001507058,0.00001146548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001207196,0.00001616206,0.0009126408,0.00008639164,0.00001600284,0.00010278,0.00001451361,0.00006802326,0.9966119,0.00002600635,0.00009665897,0.001928062],"study_design_scores_gemma":[0.00002829901,0.0005377037,0.08078869,0.00003345747,0.0001173426,0.002079158,0.0001472374,0.00357576,0.9032001,0.0001358584,0.009334138,0.00002208305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870281,0.004763159,0.003899448,0.0001703476,0.0000591503,0.00004461451,0.002111879,0.0001466985,0.001776646],"genre_scores_gemma":[0.9812475,0.002779769,0.00617413,0.0002147828,0.00002282207,0.00005464558,0.004670638,0.00004397836,0.004791882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001572028,"threshold_uncertainty_score":0.005258977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1348850933865112,"score_gpt":0.4673890675713033,"score_spread":0.3325039741847922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}