{"id":"W2740073617","doi":"10.1158/1538-7445.am2017-ct022","title":"Abstract CT022: Evaluation of oral microbiome profiling as a response biomarker in squamous cell carcinoma of the head and neck: Analyses from CheckMate 141","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Nivolumab; Medicine; Oncology; Internal medicine; Immunotherapy; Microbiome; Head and neck squamous-cell carcinoma; Biomarker; Head and neck cancer; Cancer; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008573532,0.0003395005,0.0004852518,0.0005637823,0.0004548621,0.0007676475,0.0003583881,0.0005253452,0.002209087],"category_scores_gemma":[0.001286375,0.0001354837,0.0006400781,0.0006213626,0.0002508383,0.0001820648,0.000523592,0.0004258663,0.0004547356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004355102,"about_ca_system_score_gemma":0.0005001101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003520525,"about_ca_topic_score_gemma":0.004850116,"domain_scores_codex":[0.9996505,0.00006545745,0.00002714462,0.0000900611,0.0001326954,0.00003413382],"domain_scores_gemma":[0.9991,0.0001487854,0.0001986617,0.0001234039,0.0003232215,0.0001059899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01565319,0.0009085238,0.6568039,0.0006768814,0.0008178087,0.0004740255,0.0002946803,0.001242011,0.2623403,0.0001814203,0.005743225,0.05486408],"study_design_scores_gemma":[0.0002293542,0.003217149,0.944078,0.00006356629,0.0005129087,0.0009489419,0.0002531536,0.001876239,0.04164746,0.0001030267,0.007030814,0.00003944483],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863565,0.0008501034,0.0007252458,0.0001006313,0.00002903366,0.0001664388,0.01055017,0.00004188725,0.00118012],"genre_scores_gemma":[0.9754835,0.0003697907,0.00225565,0.0003314504,0.00003428915,0.0003001287,0.01958349,0.00003341773,0.00160827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003520525,"threshold_uncertainty_score":0.007390141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3186735451048522,"score_gpt":0.5246116718909729,"score_spread":0.2059381267861207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}