{"id":"W2740132397","doi":"10.1158/1538-7445.am2017-61","title":"Abstract 61: Zymelink drug conjugate platform: redefining the therapeutic window for ADCs","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Medicine; Trastuzumab; Pharmacology; Tolerability; Antibody-drug conjugate; Drug; Therapeutic index; Neutropenia; Pharmacokinetics; Irinotecan; Cancer; Toxicity; Internal medicine; Monoclonal antibody; Breast cancer; Antibody; Adverse effect; Immunology; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001519766,0.000259693,0.0001857315,0.0001649685,0.00009752504,0.0003769608,0.0001640441,0.0003620397,0.002477365],"category_scores_gemma":[0.0001326625,0.00009398354,0.0001139589,0.0001295183,0.0001749758,0.0004250647,0.0002631251,0.0004658669,0.0006932142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004011182,"about_ca_system_score_gemma":0.0002125608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003049899,"about_ca_topic_score_gemma":0.0003008661,"domain_scores_codex":[0.9999077,0.00001266164,0.000008611775,0.00001946148,0.00003196823,0.00001963351],"domain_scores_gemma":[0.9999385,0.000008078367,0.00002180756,0.000006227921,0.00001250338,0.00001292745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001127971,0.00002686011,0.0001330614,0.00005519948,0.000003867832,0.00008516642,0.00001860478,0.0003020996,0.9929126,0.0003603846,0.0001700218,0.00581927],"study_design_scores_gemma":[0.00002682011,0.0002911036,0.0005497404,0.000005415499,0.00000616979,0.0002384983,0.000005475569,0.0008481416,0.9922616,0.00005268333,0.005709795,0.000004594221],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9729158,0.004369338,0.01231387,0.0004109003,0.00006719269,0.0001135295,0.0003548713,0.000289326,0.00916521],"genre_scores_gemma":[0.986511,0.001250596,0.005552583,0.0001026521,0.00001757826,0.00003161431,0.000310323,0.0000225993,0.006201056],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002477365,"threshold_uncertainty_score":0.008287668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2573506167744027,"score_gpt":0.4862937703441147,"score_spread":0.228943153569712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}