{"id":"W2740138820","doi":"10.1371/journal.ppat.1006520","title":"The role of co-opted ESCRT proteins and lipid factors in protection of tombusviral double-stranded RNA replication intermediate against reconstituted RNAi in yeast","year":2017,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Plant Virus Research Studies","field":"Agricultural and Biological Sciences","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Directorate for Biological Sciences; Simon Fraser University; National Science Foundation","keywords":"Biology; ESCRT; RNA silencing; RNA interference; RNA-dependent RNA polymerase; Cell biology; RNA; Viral replication; Endosome; Virology; Genetics; Gene; Virus; Intracellular","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003391651,0.00009117999,0.0001831578,0.00002821204,0.0001994149,0.00003726042,0.0002307387,0.00006426434,0.00000320883],"category_scores_gemma":[0.0003729567,0.00003502898,0.00003380284,0.0001060246,0.0002333366,0.0001276211,0.00007726303,0.0001353682,0.000001241479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002447086,"about_ca_system_score_gemma":0.00001435395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006073898,"about_ca_topic_score_gemma":0.006475228,"domain_scores_codex":[0.999108,0.00007266742,0.0002604405,0.0002126037,0.0001645709,0.0001816719],"domain_scores_gemma":[0.999497,0.0000596698,0.000215885,0.000132392,0.00006029825,0.0000347676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001751761,0.00007118718,0.06157189,0.00001142677,0.00001117443,0.000001100262,0.0001747523,9.432288e-7,0.9112928,0.00001412887,0.0000010849,0.02667436],"study_design_scores_gemma":[0.0002912818,0.0001047966,0.5252149,0.00008025715,0.000002973986,4.12943e-7,0.0002541754,0.0001555908,0.4736221,0.00008504072,0.0001258111,0.00006268853],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980338,0.0000277592,3.671379e-7,0.0001799802,0.00001975607,0.0008611244,0.0003496122,0.0000117693,0.00051581],"genre_scores_gemma":[0.99953,0.0002833881,0.000007658173,0.000002043116,0.00002672756,0.0000926508,0.00004223365,7.572677e-7,0.0000145569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.463643,"threshold_uncertainty_score":0.361333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05581072460204429,"score_gpt":0.2678297819970975,"score_spread":0.2120190573950532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}