{"id":"W2740294870","doi":"10.1158/1538-7445.am2017-ct132","title":"Abstract CT132: A Phase 2b randomized study of selinexor in patients with relapsed/refractory Diffuse Large B-Cell Lymphoma (DLBCL) demonstrates durable responses in both GCB &amp; Non-GCB subtypes","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Lymphoma; Diffuse large B-cell lymphoma; Internal medicine; Downregulation and upregulation; Oncology; Cancer research; Phases of clinical research; Refractory (planetary science); Clinical trial; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00116708,0.0001817031,0.0003919794,0.0002060195,0.000198666,0.00006552667,0.0003482088,0.0001662678,0.00004776889],"category_scores_gemma":[0.0004137495,0.0001399236,0.00005954659,0.0001412866,0.0002270192,0.00002545469,0.0001252384,0.000268796,0.000007236277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000674742,"about_ca_system_score_gemma":0.0003152584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002007038,"about_ca_topic_score_gemma":0.005250488,"domain_scores_codex":[0.9980692,0.000315478,0.0003549189,0.0004533911,0.0003741635,0.0004328111],"domain_scores_gemma":[0.9986474,0.0001066764,0.0001977308,0.0007127073,0.0002438058,0.00009166914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3416906,0.01736185,0.3504118,0.000152255,0.0001741084,0.0000401345,0.001031027,0.00002001853,0.2837021,0.000004186935,0.001357191,0.004054804],"study_design_scores_gemma":[0.5372708,0.001545204,0.4348461,0.0001229482,0.00003026695,9.92389e-7,0.0005933721,0.00002978688,0.02292091,0.00002340395,0.002313574,0.0003026523],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980308,0.0003670268,0.000007782391,0.00003925201,0.00009544652,0.0009972054,0.00005236709,0.000005089124,0.0004050657],"genre_scores_gemma":[0.9986839,0.0003059321,0.00004699669,0.00001869494,0.00007432871,0.0001248773,0.00004621415,0.00003544207,0.0006636531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2607812,"threshold_uncertainty_score":0.5705921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02194719987774465,"score_gpt":0.3411317881802795,"score_spread":0.3191845883025349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}