{"id":"W2740294870","doi":"10.1158/1538-7445.am2017-ct132","title":"Abstract CT132: A Phase 2b randomized study of selinexor in patients with relapsed/refractory Diffuse Large B-Cell Lymphoma (DLBCL) demonstrates durable responses in both GCB & Non-GCB subtypes","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Lymphoma; Diffuse large B-cell lymphoma; Internal medicine; Downregulation and upregulation; Oncology; Cancer research; Phases of clinical research; Refractory (planetary science); Clinical trial; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009984215,0.00143033,0.001452038,0.0003996201,0.0003102929,0.0008346022,0.0006584781,0.00100768,0.006495712],"category_scores_gemma":[0.0006897253,0.0004714468,0.0008284371,0.0003869783,0.001045766,0.0008312485,0.0003547391,0.002487661,0.001146883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008334519,"about_ca_system_score_gemma":0.0008908763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008836982,"about_ca_topic_score_gemma":0.003608496,"domain_scores_codex":[0.9997571,0.0001287121,0.00001159744,0.00003526769,0.00002512584,0.00004218024],"domain_scores_gemma":[0.9995351,0.00007122919,0.000079724,0.0000246895,0.00002178932,0.0002674547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8763214,0.02211448,0.004557817,0.001035572,0.00114169,0.0002066704,0.000178363,0.001433263,0.03461678,0.000300869,0.003609407,0.05448362],"study_design_scores_gemma":[0.7649665,0.2216751,0.008769957,0.00004004296,0.0002892071,0.0001742709,0.00003797056,0.000580728,0.001636521,0.0001345352,0.001672978,0.00002224867],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922125,0.00159094,0.0002546462,0.0005325044,0.0001069552,0.001871094,0.001145791,0.0001152679,0.002170317],"genre_scores_gemma":[0.9899566,0.001232643,0.0008184255,0.0006952382,0.0001343374,0.001598452,0.001880339,0.00002261519,0.003661316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006495712,"threshold_uncertainty_score":0.0217303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02194719987774465,"score_gpt":0.3411317881802795,"score_spread":0.3191845883025349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}