{"id":"W2740310721","doi":"10.1158/1538-7445.am2017-ct098","title":"Abstract CT098: Phase 1 first-in-human study of anti-clusterin antibody AB-16B5 in patients with advanced solid malignancies","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alethia Biotherapeutics (Canada); Jewish General Hospital","funders":"","keywords":"Medicine; Tolerability; Clusterin; Cancer; Internal medicine; Sarcoma; Antibody; Oncology; Bone marrow; Urology; Cancer research; Pathology; Immunology; Adverse effect; Apoptosis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000634832,0.0002032615,0.0006104071,0.0004954934,0.0002473928,0.00004252079,0.0005127063,0.00008900921,0.0003069646],"category_scores_gemma":[0.0002958107,0.0001745526,0.00004192304,0.0002514534,0.0004751232,0.0002075013,0.0004102226,0.0004999985,0.00001138807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002835596,"about_ca_system_score_gemma":0.0002261034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001693638,"about_ca_topic_score_gemma":0.003216619,"domain_scores_codex":[0.9973481,0.0001043677,0.000483743,0.0005621809,0.000812729,0.00068888],"domain_scores_gemma":[0.99787,0.00008622219,0.0001961186,0.00124584,0.0004222419,0.0001795713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003126987,0.005000161,0.9405773,0.000543021,0.00004161687,0.0007083613,0.001368423,0.0001360941,0.04694117,0.000003005184,0.00008671729,0.00146715],"study_design_scores_gemma":[0.0226682,0.002753814,0.9694275,0.000961642,0.00001622361,0.000002357889,0.0007115692,0.00002313071,0.003182598,0.000009830646,0.00008469459,0.0001584508],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968587,0.0001360993,0.000001226519,0.0001761465,0.0001122909,0.002082421,0.00006292215,0.00001631172,0.0005538921],"genre_scores_gemma":[0.999325,0.00008375294,0.000022186,0.00001651617,0.00005953368,0.0002900552,0.00002875987,0.00004545896,0.0001287842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04375857,"threshold_uncertainty_score":0.7118047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07865060191518167,"score_gpt":0.4884078122763769,"score_spread":0.4097572103611953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}