{"id":"W2740415291","doi":"10.1101/170605","title":"Targetable genetic alterations of <i>TCF4</i> (E2-2) drive immunoglobulin expression in the activated B-cell subtype of diffuse large B-cell lymphoma","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; BC Cancer Agency; University of Toronto","funders":"","keywords":"Enhancer; Gene; Lymphoma; Immunoglobulin gene; Antibody; Transcription factor; Gene expression; Diffuse large B-cell lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001104777,0.0002063001,0.0001383621,0.0001966953,0.00011361,0.0002759579,0.0001832643,0.0002330361,0.001696954],"category_scores_gemma":[0.0001015962,0.0001021907,0.0001621084,0.0001152745,0.0002241798,0.0000974451,0.0001537863,0.0004051101,0.0004784021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003661312,"about_ca_system_score_gemma":0.0001324225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009722915,"about_ca_topic_score_gemma":0.001084619,"domain_scores_codex":[0.9998972,0.00001533044,0.000007105789,0.00001956747,0.00003046979,0.00003023201],"domain_scores_gemma":[0.9999437,0.00001443184,0.00001513102,0.000008752054,0.000004252977,0.00001366119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005363043,0.00002120302,0.0002850762,0.000007899616,0.000003099721,0.00004181963,0.000004093369,0.00007070479,0.9987068,0.0001096777,0.00005629051,0.0006397091],"study_design_scores_gemma":[0.00001209282,0.00004564299,0.002229845,0.00000144372,0.000005182982,0.0001895029,0.000009074253,0.0007470092,0.9950038,0.00002876472,0.001726338,0.000001291385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994607,0.0003950257,0.002241426,0.0001142038,0.00001956966,0.00001807004,0.0004262362,0.0001317429,0.002046795],"genre_scores_gemma":[0.9948088,0.0002088778,0.001404996,0.00005128881,0.000005663318,0.00001428352,0.0005727606,0.00005312258,0.00288017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001696954,"threshold_uncertainty_score":0.005676866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007592816389019736,"score_gpt":0.2121608559923806,"score_spread":0.2045680396033609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}