{"id":"W2740434728","doi":"10.1371/journal.pone.0181490","title":"Assisted Design of Antibody and Protein Therapeutics (ADAPT)","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Research Council Canada; Québec Consortium for Drug Discovery","keywords":"Mutant; Affinities; Binding affinities; Robustness (evolution); Directed evolution; Computational biology; Antibody; Affinity maturation; Protein engineering; Rational design; Chemistry; Biology; Biophysics; Genetics; Biochemistry; Receptor; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000919937,0.001088334,0.000778185,0.0004455691,0.0002150398,0.0005948702,0.0008293695,0.0007054035,0.001571582],"category_scores_gemma":[0.00074541,0.0004823492,0.000906494,0.000288651,0.0003377797,0.0002847989,0.0008234226,0.0009389942,0.0007363969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003882808,"about_ca_system_score_gemma":0.0007442995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003192176,"about_ca_topic_score_gemma":0.0004865871,"domain_scores_codex":[0.9994946,0.0001119989,0.00002354481,0.00008542755,0.0002218888,0.00006261157],"domain_scores_gemma":[0.9997949,0.00006487288,0.00005097188,0.00002085442,0.00004262439,0.00002568111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006063727,0.0004166372,0.0035354,0.0008395428,0.0003514016,0.0005968033,0.00009697,0.3599741,0.4493666,0.01498516,0.004074478,0.1651566],"study_design_scores_gemma":[0.0003188297,0.002766247,0.001377044,0.00005313212,0.0002195689,0.0006984236,0.00005475168,0.7009884,0.2412927,0.004808103,0.0473324,0.00009032356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2703764,0.002346699,0.711404,0.0002804139,0.0001949757,0.0006708343,0.0006490809,0.004511323,0.009566219],"genre_scores_gemma":[0.4815536,0.001526473,0.5088035,0.0003609269,0.00003724303,0.0007806977,0.001116435,0.0003569588,0.005464192],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001571582,"threshold_uncertainty_score":0.005257487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2426063510266915,"score_gpt":0.3652329159295718,"score_spread":0.1226265649028803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}