{"id":"W2740470992","doi":"10.1158/1538-7445.am2017-lb-103","title":"Abstract LB-103: Landscape of somatic ERBB2 Mutations: Findings from AACR GENIE and comparison to ongoing ERBB2 mutant basket study","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Missense mutation; Cohort; Neratinib; Indel; Cancer; Medicine; Breast cancer; Oncology; Exome; Colorectal cancer; Germline mutation; Internal medicine; Mutation; Genetics; Exome sequencing; Biology; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002456474,0.0003156824,0.0005389857,0.001047381,0.0003022274,0.000877286,0.0006720517,0.0005179392,0.002037667],"category_scores_gemma":[0.002782288,0.0001627355,0.0004371975,0.00187512,0.0004536507,0.000569292,0.0009771205,0.0004371446,0.00055962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001000566,"about_ca_system_score_gemma":0.0004593208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008291398,"about_ca_topic_score_gemma":0.01331481,"domain_scores_codex":[0.9990129,0.0003210544,0.00006209876,0.0002740491,0.0001995159,0.0001304182],"domain_scores_gemma":[0.9981002,0.0004391452,0.0006202668,0.0003474999,0.0002908649,0.0002019317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00416284,0.00008912375,0.9737932,0.00007316865,0.0002490301,0.0004021511,0.0003275231,0.0004211705,0.005464808,0.000104244,0.002209857,0.01270293],"study_design_scores_gemma":[0.0001464316,0.0005356324,0.9953024,0.00001462533,0.0001296172,0.000869064,0.0002424077,0.0003456876,0.000655119,0.00006536783,0.001681338,0.00001226075],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944053,0.0004767521,0.000151083,0.0001438563,0.000002861199,0.0000231352,0.00338063,0.00003199119,0.001384495],"genre_scores_gemma":[0.9941361,0.000160365,0.0002038734,0.0001682555,0.000007713981,0.00002329758,0.00501227,0.00002435821,0.0002638249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008291398,"threshold_uncertainty_score":0.01648629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1213076408799797,"score_gpt":0.4710490454831226,"score_spread":0.349741404603143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}