{"id":"W2740470992","doi":"10.1158/1538-7445.am2017-lb-103","title":"Abstract LB-103: Landscape of somatic ERBB2 Mutations: Findings from AACR GENIE and comparison to ongoing ERBB2 mutant basket study","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Missense mutation; Cohort; Neratinib; Indel; Cancer; Medicine; Breast cancer; Oncology; Exome; Colorectal cancer; Germline mutation; Internal medicine; Mutation; Genetics; Exome sequencing; Biology; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007395583,0.0001943817,0.0005652034,0.0002768291,0.0004944516,0.0001326398,0.000388016,0.00007473189,0.0005525453],"category_scores_gemma":[0.000518306,0.0001713429,0.00005294016,0.000218895,0.0002807661,0.000234649,0.0002364492,0.0004850776,0.00004414265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002370224,"about_ca_system_score_gemma":0.0003183709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003585058,"about_ca_topic_score_gemma":0.001662763,"domain_scores_codex":[0.9975829,0.00007806747,0.000433331,0.0004960211,0.0008999476,0.0005097505],"domain_scores_gemma":[0.9978996,0.0003997148,0.0001622466,0.0008715713,0.0003760071,0.0002908472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001478205,0.0005642289,0.7560088,0.0004224984,0.0004473529,0.0001074087,0.01612647,0.0001407527,0.1782056,0.00002881152,0.0004659832,0.04600389],"study_design_scores_gemma":[0.003750113,0.0005213914,0.957725,0.0008703108,0.00007340177,0.000007067525,0.008832856,0.0002334287,0.02648539,0.0004771556,0.0008231922,0.000200689],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947029,0.001765335,0.00007661668,0.001378399,0.0001279563,0.001330313,0.0001027676,0.00003561975,0.000480043],"genre_scores_gemma":[0.9983464,0.00008981692,0.0007282579,0.0000539208,0.0002290452,0.0002920011,0.00001387477,0.00004678647,0.0001998382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2017162,"threshold_uncertainty_score":0.6987159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1213076408799797,"score_gpt":0.4710490454831226,"score_spread":0.349741404603143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}