{"id":"W2740527601","doi":"10.1107/s2053230x17009669","title":"1.12 Å resolution crystal structure of the catalytic domain of the plasmid-mediated colistin resistance determinant MCR-2","year":2017,"lang":"en","type":"article","venue":"Acta Crystallographica Section F Structural Biology Communications","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Diamond Light Source","keywords":"Colistin; Plasmid; MCR-1; Transferase; Resolution (logic); Biology; Crystal structure; Microbiology; Chemistry; Genetics; Antibiotics; Escherichia coli; Crystallography; Gene; Biochemistry; Enzyme; Enterobacteriaceae; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005760462,0.0006377171,0.001034555,0.0003144413,0.0006863274,0.0009184591,0.001023146,0.001075589,0.004669881],"category_scores_gemma":[0.000916209,0.0004959447,0.0002883039,0.0006416689,0.000218668,0.0005464783,0.0002947623,0.002568502,0.000983167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00111103,"about_ca_system_score_gemma":0.001681136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008910635,"about_ca_topic_score_gemma":0.009351406,"domain_scores_codex":[0.9997502,0.00003527458,0.00001028236,0.00003926834,0.0001222529,0.00004269201],"domain_scores_gemma":[0.9997334,0.00005754238,0.00003552462,0.00001224876,0.00008740576,0.00007393508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003858672,0.001097644,0.008369671,0.002495541,0.0003655408,0.004101276,0.0009827361,0.01380483,0.7175587,0.01377597,0.1811201,0.05246934],"study_design_scores_gemma":[0.005024829,0.002203488,0.1355252,0.0007703658,0.0006178881,0.006070745,0.002425612,0.09600221,0.2134034,0.010277,0.5270755,0.0006036985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8584729,0.03188749,0.01423781,0.007894561,0.002481529,0.0003650766,0.0364556,0.002419072,0.04578593],"genre_scores_gemma":[0.8331077,0.01399568,0.03866796,0.001639674,0.0003111506,0.000247915,0.08300128,0.000337879,0.02869078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008910635,"threshold_uncertainty_score":0.01771754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01174803268766134,"score_gpt":0.2591786727894804,"score_spread":0.247430640101819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}