{"id":"W2740538710","doi":"10.1172/jci.insight.93230","title":"HIV-1 selectively targets gut-homing CCR6+CD4+ T cells via mTOR-dependent mechanisms","year":2017,"lang":"en","type":"article","venue":"JCI Insight","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Caprion (Canada); Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Permissiveness; C-C chemokine receptor type 6; PI3K/AKT/mTOR pathway; Biology; Homing (biology); Chemokine receptor; Downregulation and upregulation; Protein kinase B; Cancer research; Cell biology; Immunology; Signal transduction; Viral replication; Immune system; Chemokine; Virus; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001038218,0.0002012826,0.0002702181,0.0001769698,0.0001668986,0.0004904713,0.0001001173,0.0002143551,0.002307034],"category_scores_gemma":[0.0001025402,0.0001039454,0.000256057,0.0001378672,0.0001216399,0.0001573465,0.0001711632,0.0003611369,0.0004211776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001252847,"about_ca_system_score_gemma":0.000141444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002571523,"about_ca_topic_score_gemma":0.0005951033,"domain_scores_codex":[0.9998155,0.00003582729,0.00001148712,0.00003799166,0.00003754553,0.00006169913],"domain_scores_gemma":[0.9999378,0.000007152009,0.00002242468,0.000005946303,0.000008111773,0.00001855621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003221693,0.00003183496,0.001656906,0.0001432474,0.0000113122,0.00007752323,0.00002593775,0.0001014882,0.9924305,0.00007598285,0.000115791,0.005007262],"study_design_scores_gemma":[0.00007296498,0.001714123,0.09696478,0.00007226644,0.0001212259,0.001568299,0.0002766288,0.00196849,0.8863219,0.0002233408,0.01067437,0.00002151565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897261,0.00669142,0.0008662958,0.0001136442,0.00002921698,0.00004015084,0.00061049,0.00005947415,0.001863037],"genre_scores_gemma":[0.9935976,0.002308069,0.001501262,0.00009326581,0.00003738555,0.00003807255,0.0005297383,0.00001446742,0.001880107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002307034,"threshold_uncertainty_score":0.007717788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01734673700121626,"score_gpt":0.2577515717269687,"score_spread":0.2404048347257525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}