{"id":"W2740538710","doi":"10.1172/jci.insight.93230","title":"HIV-1 selectively targets gut-homing CCR6+CD4+ T cells via mTOR-dependent mechanisms","year":2017,"lang":"en","type":"article","venue":"JCI Insight","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Caprion (Canada); Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Permissiveness; C-C chemokine receptor type 6; PI3K/AKT/mTOR pathway; Biology; Homing (biology); Chemokine receptor; Downregulation and upregulation; Protein kinase B; Cancer research; Cell biology; Immunology; Signal transduction; Viral replication; Immune system; Chemokine; Virus; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000199947,0.0002778565,0.0003469692,0.0001232963,0.001175327,0.00009904986,0.0005493651,0.000289295,0.001815684],"category_scores_gemma":[0.00006850145,0.0002254654,0.0001309559,0.00004677758,0.0001728273,0.0002189168,0.0002795347,0.0004047276,0.01611277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001553271,"about_ca_system_score_gemma":0.0001130903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002866274,"about_ca_topic_score_gemma":0.0001190884,"domain_scores_codex":[0.9982678,0.0001598922,0.0002423921,0.0005064964,0.00009991656,0.0007235567],"domain_scores_gemma":[0.9988261,0.00007539929,0.0001727213,0.0007231273,0.0001123024,0.00009033459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001745678,0.0003895708,0.0007970826,0.00001404186,0.0004360073,0.0001944424,0.0005870615,0.000001691786,0.9803032,0.001166943,0.009361901,0.006573434],"study_design_scores_gemma":[0.002401179,0.0003907782,0.0072616,0.00002097404,0.00004654662,0.00005122698,0.00005934821,0.000007551951,0.842566,0.001006099,0.145885,0.0003037435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6919414,0.01307989,0.03329419,0.00439207,0.0109369,0.004474073,0.00132825,0.0009913864,0.2395618],"genre_scores_gemma":[0.9761077,0.0001243545,0.0004796689,0.00009675042,0.00006365449,0.00007531132,0.0001296835,0.00003308045,0.02288976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2841663,"threshold_uncertainty_score":0.9990968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01734673700121626,"score_gpt":0.2577515717269687,"score_spread":0.2404048347257525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}