{"id":"W2740846152","doi":"10.1002/stem.2655","title":"Brief Report: Human Acute Myeloid Leukemia Reprogramming to Pluripotency Is a Rare Event and Selects for Patient Hematopoietic Cells Devoid of Leukemic Mutations","year":2017,"lang":"en","type":"article","venue":"Stem Cells","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Reprogramming; Biology; Myeloid leukemia; Induced pluripotent stem cell; Haematopoiesis; Cancer research; Leukemia; Myeloid; Stem cell; Population; Immunology; Genetics; Cell; Embryonic stem cell; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005858664,0.0003691431,0.0007730384,0.0002589248,0.0006767674,0.0001248425,0.0003824276,0.0002155728,0.00004848197],"category_scores_gemma":[0.0001256933,0.0003486583,0.0002522023,0.0002189137,0.0002333309,0.0001705242,0.0003615366,0.0003543055,0.00003178999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009084841,"about_ca_system_score_gemma":0.001022964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004214402,"about_ca_topic_score_gemma":0.00003907834,"domain_scores_codex":[0.9965675,0.00005912353,0.0009995408,0.0009522701,0.0006616644,0.0007598443],"domain_scores_gemma":[0.9963065,0.0001423296,0.0007081738,0.001712962,0.000616644,0.0005134274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003877835,0.0002002128,0.001483793,0.0017782,0.0005232351,0.001219637,0.009964112,0.00004185436,0.9332148,0.0001143083,0.01581099,0.03526101],"study_design_scores_gemma":[0.003058365,0.001465009,0.001512194,0.000675712,0.0004154841,0.0007401228,0.001072075,0.0003533785,0.9775178,0.0002091804,0.01253285,0.0004478674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931656,0.0002865212,0.001197909,0.0007584271,0.0002053555,0.003375951,0.0001121557,0.00007729078,0.000820866],"genre_scores_gemma":[0.9852346,0.00006682555,0.0061975,0.0002700611,0.00012312,0.0003426756,0.00005965698,0.00009777995,0.007607769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04430291,"threshold_uncertainty_score":0.9998965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01942503573374269,"score_gpt":0.3097946691394899,"score_spread":0.2903696334057472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}