{"id":"W2740847816","doi":"10.7554/elife.23783","title":"A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres","year":2017,"lang":"en","type":"article","venue":"eLife","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Krembil Foundation; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Telomere; Telomerase; Biology; DNA; Telomerase RNA component; Cell biology; Molecular biology; Genetics; Telomerase reverse transcriptase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002809677,0.000425788,0.000738354,0.0001173071,0.0005530445,0.000354577,0.0006477358,0.000268055,0.001126391],"category_scores_gemma":[0.0002554732,0.0003613147,0.0002211582,0.00007736529,0.000381982,0.0003575092,0.0001914684,0.000493428,0.0005548616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006234241,"about_ca_system_score_gemma":0.0002151699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009090976,"about_ca_topic_score_gemma":0.0004959523,"domain_scores_codex":[0.9969323,0.00002687787,0.0005653705,0.0007914902,0.0009622196,0.0007217645],"domain_scores_gemma":[0.9972537,0.0001148865,0.0001060671,0.001546131,0.0003330506,0.0006462124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005934579,0.001818416,0.6837252,0.0004081485,0.001089608,0.003760709,0.002166065,0.00001227068,0.225812,0.002767046,0.04565018,0.02685579],"study_design_scores_gemma":[0.008624412,0.0004788186,0.668449,0.0006742007,0.0005299594,0.0002338352,0.0004839655,0.0003969267,0.285336,0.0004922188,0.03310178,0.001198801],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9659535,0.001428443,0.00008600805,0.003312373,0.000664426,0.0005389514,0.0001582293,0.0002307447,0.02762737],"genre_scores_gemma":[0.9926716,0.0004154545,0.0005472866,0.00203168,0.001125499,0.00004539032,0.0001063349,0.0000669939,0.002989725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05952406,"threshold_uncertainty_score":0.9998839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04778354457058334,"score_gpt":0.3348163804051286,"score_spread":0.2870328358345452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}