{"id":"W2740908790","doi":"10.1002/ppul.23777","title":"mTOR‐Notch3 signaling mediates pulmonary hypertension in hypoxia‐exposed neonatal rats independent of changes in autophagy","year":2017,"lang":"en","type":"article","venue":"Pediatric Pulmonology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Toronto; University of Ottawa; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Autophagy; PI3K/AKT/mTOR pathway; Notch signaling pathway; Medicine; Hypoxia (environmental); Sirolimus; Pulmonary hypertension; Signal transduction; Cancer research; Pharmacology; Cell biology; Internal medicine; Biology; Receptor; Chemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001934847,0.0004880006,0.0004698773,0.0003485064,0.0002170356,0.0001955665,0.0003310728,0.0003432701,0.002212269],"category_scores_gemma":[0.0001426631,0.0002700553,0.00039542,0.0001057333,0.0005899646,0.000395326,0.0002991226,0.001092361,0.0002873602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004171493,"about_ca_system_score_gemma":0.0004575793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006988981,"about_ca_topic_score_gemma":0.001107826,"domain_scores_codex":[0.9998471,0.00001743294,0.00001774958,0.00004439308,0.00003013967,0.00004317679],"domain_scores_gemma":[0.999733,0.00001468311,0.00009868359,0.00002657832,0.00002426642,0.0001027008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002657102,0.000204738,0.001103256,0.0001030897,0.00001964954,0.0002044943,0.00005379382,0.00005339449,0.9923504,0.0001265555,0.0001001552,0.003023434],"study_design_scores_gemma":[0.0001636301,0.002917021,0.02991522,0.00002648804,0.00008849999,0.0005720655,0.0001992236,0.001065935,0.9633237,0.000173002,0.001537569,0.00001769313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969085,0.000974266,0.001117978,0.0001305219,0.00004638623,0.00001944104,0.0002740412,0.00006388292,0.0004649966],"genre_scores_gemma":[0.9939848,0.0009919722,0.001254348,0.000108329,0.00002889076,0.0001335098,0.000405344,0.00002792915,0.003064862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002212269,"threshold_uncertainty_score":0.007400751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02454606781466393,"score_gpt":0.2675966746617984,"score_spread":0.2430506068471345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}