{"id":"W2741004392","doi":"10.1158/1538-7445.am2017-2795","title":"Abstract 2795: Integrating multiomics discovery approaches to identify biomarkers of therapeutic resistance in metastatic colorectal cancer through analyses of multiple sequential tumor and liquid biopsies; Qcroc01: NCT00984048","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Moncton Hospital; Mount Sinai Hospital; Jewish General Hospital; Sunnybrook Health Science Centre; Dr. Georges-L.-Dumont University Hospital Centre; Hôpital Maisonneuve-Rosemont; St Mary's Hospital Centre; McGill University Health Centre; Simon Fraser University; Hôpital du Sacré-Cœur de Montréal; Hôtel-Dieu de Québec; Hôpital Charles-Le Moyne; Centre Hospitalier de l’Université de Montréal; Quebec - Clinical Research Organization in Cancer","funders":"","keywords":"Colorectal cancer; Metastasis; Cancer; Transcriptome; Loss of heterozygosity; Liquid biopsy; KRAS; Medicine; Somatic evolution in cancer; Oncology; Cancer research; Biology; Pathology; Internal medicine; Gene; Genetics; Allele; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001742329,0.0004654247,0.000759559,0.0007863202,0.0003827563,0.0008038235,0.0005526164,0.0006115644,0.002960748],"category_scores_gemma":[0.001090469,0.0002443826,0.0003550745,0.00073531,0.000349736,0.000207302,0.0005505348,0.0007861928,0.0006115405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007467559,"about_ca_system_score_gemma":0.001073702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004111936,"about_ca_topic_score_gemma":0.007584373,"domain_scores_codex":[0.9992864,0.0001847397,0.00003721837,0.0001770001,0.0002488183,0.00006589608],"domain_scores_gemma":[0.9994889,0.00009904763,0.0001074029,0.00005033967,0.0001729611,0.00008131391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007093858,0.001688767,0.09947254,0.0006264646,0.0004556594,0.0005218905,0.0001790305,0.002826091,0.8217766,0.0003925457,0.009509991,0.05545668],"study_design_scores_gemma":[0.001446774,0.0105743,0.7087196,0.0001010416,0.0007060578,0.002231234,0.0005012064,0.03685264,0.2145312,0.0007960527,0.02343264,0.0001072898],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9504969,0.002937482,0.01282313,0.001440244,0.000116412,0.001388249,0.02695007,0.0005136817,0.003333984],"genre_scores_gemma":[0.9346219,0.001044429,0.0327808,0.001170203,0.00007658987,0.001601663,0.0245803,0.0001543821,0.003969802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004111936,"threshold_uncertainty_score":0.009904683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2314340966918284,"score_gpt":0.4506600613212599,"score_spread":0.2192259646294315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}