{"id":"W2741029033","doi":"10.3390/biom7030057","title":"Metal Binding Properties of the N-Terminus of the Functional Amyloid Orb2","year":2017,"lang":"en","type":"article","venue":"Biomolecules","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; University of Southern California; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Whitehall Foundation","keywords":"Isothermal titration calorimetry; Histidine; Thioflavin; Binding domain; Chemistry; Amyloid (mycology); Binding site; Biophysics; Binding selectivity; Mutagenesis; Biochemistry; Circular dichroism; Crystallography; Stereochemistry; Biology; Mutation; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001442174,0.0002489224,0.0001518777,0.0001055517,0.0001595211,0.000154166,0.0001998341,0.0002079598,0.0006417778],"category_scores_gemma":[0.000282323,0.0000779599,0.0002347969,0.0001359482,0.0001663986,0.0001312337,0.00013543,0.0003303291,0.0002304874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003080466,"about_ca_system_score_gemma":0.0001154395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0019118,"about_ca_topic_score_gemma":0.001150001,"domain_scores_codex":[0.9999057,0.00001521121,0.000007442095,0.00002201274,0.00003180511,0.00001789809],"domain_scores_gemma":[0.999863,0.00003335657,0.0000226084,0.00001217493,0.00003593226,0.00003284061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001340888,0.00001642585,0.0003565423,0.00001404987,0.000004264108,0.00005057135,0.00001576053,0.00005547866,0.9989827,0.00002904295,0.00001799628,0.0003230918],"study_design_scores_gemma":[0.00001463902,0.0001057401,0.01136041,0.000004432769,0.0000112931,0.0003129279,0.00003246114,0.001765725,0.9852145,0.00003454301,0.001133363,0.000009925055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982209,0.0003971378,0.0007820339,0.00002697689,0.000009267825,0.000004601375,0.0001851561,0.000007235908,0.0003665749],"genre_scores_gemma":[0.9970775,0.0001385153,0.0009329592,0.00003459247,0.00000737555,0.000008695017,0.0008963389,0.00001377338,0.0008903632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0019118,"threshold_uncertainty_score":0.003801405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06309675577387737,"score_gpt":0.299755190553224,"score_spread":0.2366584347793467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}