{"id":"W2741029033","doi":"10.3390/biom7030057","title":"Metal Binding Properties of the N-Terminus of the Functional Amyloid Orb2","year":2017,"lang":"en","type":"article","venue":"Biomolecules","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; University of Southern California; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Whitehall Foundation","keywords":"Isothermal titration calorimetry; Histidine; Thioflavin; Binding domain; Chemistry; Amyloid (mycology); Binding site; Biophysics; Binding selectivity; Mutagenesis; Biochemistry; Circular dichroism; Crystallography; Stereochemistry; Biology; Mutation; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000633739,0.00007751646,0.0001282662,0.00002898298,0.0002321635,0.00001451563,0.0002064964,0.00002839896,0.00003886493],"category_scores_gemma":[0.0001210479,0.00003311481,0.0001687682,0.00005248558,0.0006078973,0.00004386511,0.0001609208,0.00005038675,0.00001497209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001818035,"about_ca_system_score_gemma":0.0001809565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000115407,"about_ca_topic_score_gemma":0.00001135525,"domain_scores_codex":[0.9992489,0.00003704203,0.0001179859,0.0001046911,0.0003628787,0.0001284827],"domain_scores_gemma":[0.9992245,0.000009366414,0.0001250759,0.0005020627,0.00008499301,0.00005394552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006517317,0.0008559929,0.230005,0.0002557491,0.006652198,0.00007080363,0.0001692713,5.743149e-7,0.7563121,0.0008756904,0.0007849722,0.003365894],"study_design_scores_gemma":[0.0007113786,0.00006565293,0.2956394,0.0001638738,0.0003117425,0.00003118791,0.00006064239,0.00001154447,0.702813,0.00003658915,0.0001148935,0.00004005978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957561,0.001878933,0.00000215966,0.0006850535,0.0001104572,0.0002599803,0.00003379804,0.00000568225,0.001267822],"genre_scores_gemma":[0.9995162,0.0000165244,0.00001906361,0.00001913997,0.00003726595,0.00001300855,0.000002828963,0.000008228696,0.0003677632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06563447,"threshold_uncertainty_score":0.2239823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06309675577387737,"score_gpt":0.299755190553224,"score_spread":0.2366584347793467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}