{"id":"W2741035828","doi":"10.1200/jco.2012.30.15_suppl.tps8116","title":"Phase I/II open-label, multiple-dose, dose-escalation study to evaluate the safety and tolerability of SNS01T administered by intravenous infusion in patients with relapsed or refractory multiple myeloma.","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Medicine; Tolerability; Multiple myeloma; Apoptosis; In vivo; Pharmacology; Internal medicine; Cancer research; Adverse effect; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007799563,0.001553965,0.002194666,0.0003988105,0.000358106,0.000763703,0.000803392,0.001041243,0.005126965],"category_scores_gemma":[0.0004647962,0.0005295416,0.0008745673,0.0004341172,0.000789155,0.0008276792,0.0002836983,0.002648997,0.001120291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001074962,"about_ca_system_score_gemma":0.00142859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007698976,"about_ca_topic_score_gemma":0.001845465,"domain_scores_codex":[0.9998075,0.00006299737,0.000008177495,0.00004726198,0.00003079842,0.00004324258],"domain_scores_gemma":[0.9996393,0.00003061886,0.00008546566,0.00003445054,0.00002531177,0.0001849809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.532742,0.1246144,0.005008011,0.001598674,0.001544101,0.0003772953,0.0004414407,0.006624557,0.1560105,0.0006614422,0.007686291,0.1626914],"study_design_scores_gemma":[0.2609111,0.710533,0.007762635,0.00005587918,0.0003853065,0.0004252218,0.00007744912,0.002843178,0.01020089,0.0003398723,0.006424345,0.00004113261],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891372,0.001953128,0.001567117,0.0003808253,0.0001761193,0.003291878,0.001189266,0.0001750026,0.002129403],"genre_scores_gemma":[0.9801981,0.001857546,0.003984969,0.0007571656,0.0001413864,0.004956208,0.002301942,0.00006691538,0.005735717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005126965,"threshold_uncertainty_score":0.01715136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08459361967065941,"score_gpt":0.4395891438832487,"score_spread":0.3549955242125893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}