{"id":"W2741035828","doi":"10.1200/jco.2012.30.15_suppl.tps8116","title":"Phase I/II open-label, multiple-dose, dose-escalation study to evaluate the safety and tolerability of SNS01T administered by intravenous infusion in patients with relapsed or refractory multiple myeloma.","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Medicine; Tolerability; Multiple myeloma; Apoptosis; In vivo; Pharmacology; Internal medicine; Cancer research; Adverse effect; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003624175,0.0001490149,0.0007288238,0.00004528688,0.0000995453,0.00001012102,0.0003471822,0.0001885617,0.00001206226],"category_scores_gemma":[0.003401035,0.00008569111,0.00005088109,0.0001442896,0.0001529989,0.00002959131,0.0003250767,0.000340646,0.000001004183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003255516,"about_ca_system_score_gemma":0.0003515253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000335391,"about_ca_topic_score_gemma":0.0002565168,"domain_scores_codex":[0.9967294,0.0008578902,0.001729649,0.0002386747,0.0002313267,0.000213082],"domain_scores_gemma":[0.9974125,0.0006961759,0.0009820045,0.0003583251,0.0003089057,0.0002420672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05989819,0.0633118,0.5318727,0.00001194464,0.0001751429,0.000002486089,0.00081021,0.00001252238,0.02620799,0.000005566826,0.0006032236,0.3170882],"study_design_scores_gemma":[0.04240037,0.05244109,0.8808584,0.00001767598,0.0001108253,0.000004664117,0.0002009593,0.00005430115,0.0007857573,0.00000658528,0.02299623,0.0001231535],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977864,0.0001528107,0.0001874453,0.0004481295,0.0002192444,0.001102512,0.00004469704,0.000001733584,0.00005704906],"genre_scores_gemma":[0.9980444,0.0001005433,0.001213814,0.0003496218,0.0001742251,0.00002045321,0.00003308996,0.00001336805,0.00005047646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3489857,"threshold_uncertainty_score":0.4071603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08459361967065941,"score_gpt":0.4395891438832487,"score_spread":0.3549955242125893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}