{"id":"W2741056151","doi":"10.1158/1538-7445.am2017-2653","title":"Abstract 2653: The anti-myeloma activity of TTI-621 (SIRPαFc), a CD47-blocking immunotherapeutic, is enhanced when combined with a proteasome inhibitor","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trillium Therapeutics (Canada)","funders":"","keywords":"CD47; Cancer research; Bortezomib; Phagocytosis; Macrophage; Proteasome inhibitor; Immune system; Immunology; Multiple myeloma; Medicine; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009935427,0.0002115254,0.0004145586,0.0001247363,0.001295813,0.0001281845,0.0008673177,0.0002211288,0.0006299846],"category_scores_gemma":[0.00008718215,0.0001371005,0.0001103155,0.0001340561,0.001134292,0.000338665,0.0002545186,0.0007677627,0.00005566609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000139161,"about_ca_system_score_gemma":0.0003861439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001414555,"about_ca_topic_score_gemma":0.0001324057,"domain_scores_codex":[0.9981953,0.0002909136,0.0002798168,0.0003995833,0.0002208411,0.0006135804],"domain_scores_gemma":[0.9978065,0.0001799927,0.0003703797,0.001195719,0.0004199351,0.00002742094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001555442,0.0001610717,0.001637734,0.00006873137,0.000338551,0.000001474732,0.001393883,0.000002198979,0.9665308,0.00009206826,0.0004602087,0.02775782],"study_design_scores_gemma":[0.00178841,0.0003145112,0.1968333,0.0002510823,0.00001870465,0.000003903172,0.0001118367,0.000005309455,0.7964472,0.000112932,0.003971009,0.0001417719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926124,0.002912126,0.00002762017,0.00221471,0.0002187568,0.001084907,0.00003204785,0.00002613489,0.0008713131],"genre_scores_gemma":[0.9973943,0.0003311474,0.00001248462,0.00004071383,0.00006988697,0.0003133731,0.000007617106,0.00003469137,0.001795833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1951956,"threshold_uncertainty_score":0.996648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06647886095438363,"score_gpt":0.3651098816259278,"score_spread":0.2986310206715441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}