{"id":"W2741098695","doi":"10.1158/1538-7445.am2017-5433","title":"Abstract 5433: β-Tubulin inhibitors reduce GLUT1 membrane trafficking to attenuate tumorigenesis in glioblastoma subtypes","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"GLUT1; Carcinogenesis; Cancer research; Downregulation and upregulation; Mesenchymal stem cell; Warburg effect; Biology; Cancer cell; Tumor microenvironment; Cancer stem cell; Stem cell; Cancer; Cell biology; Glucose transporter; Chemistry; Biochemistry; Endocrinology; Genetics; Tumor cells; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006321449,0.0004013978,0.0003248128,0.0002570167,0.0001538227,0.0001950495,0.0001673917,0.0002485593,0.003295586],"category_scores_gemma":[0.00005936974,0.0001250304,0.0002475416,0.0002054237,0.0001268157,0.0001100825,0.00009868214,0.0005892995,0.0005102445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002529494,"about_ca_system_score_gemma":0.0002994687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001416345,"about_ca_topic_score_gemma":0.002396479,"domain_scores_codex":[0.9999535,0.000005428122,0.000005004179,0.00000866945,0.00001017887,0.00001721737],"domain_scores_gemma":[0.9999723,0.000002120754,0.000007239713,0.00000226991,0.000005255713,0.0000107565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007841761,0.0002466446,0.0002748993,0.0001413922,0.00002388623,0.00004084779,0.00001725064,0.00009561227,0.9913607,0.00008001072,0.0007490629,0.006185627],"study_design_scores_gemma":[0.00015353,0.002892359,0.008387821,0.00002038786,0.000074743,0.000171111,0.00005167475,0.0009699283,0.981277,0.00005695608,0.005937603,0.000006819269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933618,0.002367625,0.001064211,0.0002721379,0.0001287691,0.00005931497,0.0008412629,0.000215439,0.001689514],"genre_scores_gemma":[0.9884194,0.002285841,0.001279806,0.0002067332,0.00002256354,0.00009994449,0.001513156,0.00003994214,0.006132624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003295586,"threshold_uncertainty_score":0.01102489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04383007522533303,"score_gpt":0.3727595579142421,"score_spread":0.328929482688909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}