{"id":"W2741099473","doi":"10.3389/fnagi.2017.00249","title":"DNA Methylation of Synaptic Genes in the Prefrontal Cortex Is Associated with Aging and Age-Related Cognitive Impairment","year":2017,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Genetics","funders":"National Institute on Aging","keywords":"DNA methylation; Epigenetics; Prefrontal cortex; Biology; CpG site; Methylation; Gene; Genetics; Neuroscience; Gene expression; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001242273,0.0001920333,0.0001891759,0.000511486,0.0000974463,0.000100417,0.0001253052,0.0001727364,0.0004637579],"category_scores_gemma":[0.0001726925,0.00009403554,0.0001185763,0.0001830935,0.0001555798,0.00008065454,0.0001465001,0.0001348158,0.0000631623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001472233,"about_ca_system_score_gemma":0.0001109194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001701234,"about_ca_topic_score_gemma":0.001965743,"domain_scores_codex":[0.9999464,0.000005549466,0.000003657281,0.00002130534,0.00001303178,0.00001009918],"domain_scores_gemma":[0.9998348,0.00001115893,0.000100428,0.00001023084,0.00002215064,0.00002111826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007503419,0.00003781549,0.08183746,0.00006059912,0.00009828266,0.0002725976,0.0001627131,0.000109584,0.9059044,0.00007732458,0.00006663252,0.01062225],"study_design_scores_gemma":[0.000007265505,0.0002697678,0.9569688,0.000005056472,0.00006494128,0.0007058516,0.00007511491,0.0002470717,0.04109666,0.0002032411,0.0003491994,0.000007038309],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981817,0.0007954797,0.0006760536,0.00001782103,0.000002225319,0.00000305753,0.0001408604,0.00001193201,0.0001708722],"genre_scores_gemma":[0.9986606,0.0004302177,0.0004071541,0.00001351875,0.000003772511,0.000005806185,0.000124663,0.000002736957,0.0003515514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001701234,"threshold_uncertainty_score":0.003382683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01347855399037509,"score_gpt":0.2624117848128006,"score_spread":0.2489332308224255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}