{"id":"W2741219503","doi":"10.1158/1078-0432.ccr-17-1140","title":"Circulating Tumor DNA Reveals Clinically Actionable Somatic Genome of Metastatic Bladder Cancer","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation; BC Cancer Agency; University of British Columbia","funders":"","keywords":"ARID1A; Bladder cancer; Somatic hypermutation; Cancer research; Metastasis; Targeted therapy; Cancer; Exome; Medicine; Biology; Exome sequencing; Oncology; Gene; Mutation; Internal medicine; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001945058,0.0002056798,0.0002096231,0.0006282883,0.0001732599,0.0003243397,0.0001469024,0.0002933963,0.001876274],"category_scores_gemma":[0.0008095495,0.0001232312,0.00009425108,0.0003741792,0.0001976952,0.0001326978,0.000247744,0.0002363615,0.0002280955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002273677,"about_ca_system_score_gemma":0.000161823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005747917,"about_ca_topic_score_gemma":0.000853964,"domain_scores_codex":[0.9998208,0.00002225916,0.00001597153,0.00006982056,0.00004538274,0.0000258428],"domain_scores_gemma":[0.9997473,0.00008828755,0.00005713345,0.0000221729,0.00004405212,0.00004096983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007491321,0.00005078276,0.1837475,0.0001470129,0.00005065883,0.0006885721,0.0002317819,0.0005385797,0.7900632,0.000201443,0.0002226403,0.02330874],"study_design_scores_gemma":[0.00006606595,0.001163699,0.6091926,0.00004644296,0.0001545587,0.01354685,0.0002927514,0.005514306,0.3657617,0.0005570916,0.003681905,0.00002193819],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964448,0.0004647445,0.002200256,0.000037536,0.000005953649,0.000009393384,0.0003912087,0.00004006741,0.0004061295],"genre_scores_gemma":[0.9983278,0.00008218443,0.001060753,0.00002757006,0.000004730786,0.000007848059,0.00029017,0.000006156418,0.0001927913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001876274,"threshold_uncertainty_score":0.006276727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2092261080348713,"score_gpt":0.5197973101985911,"score_spread":0.3105712021637198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}