{"id":"W2741219503","doi":"10.1158/1078-0432.ccr-17-1140","title":"Circulating Tumor DNA Reveals Clinically Actionable Somatic Genome of Metastatic Bladder Cancer","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation; BC Cancer Agency; University of British Columbia","funders":"","keywords":"ARID1A; Bladder cancer; Somatic hypermutation; Cancer research; Metastasis; Targeted therapy; Cancer; Exome; Medicine; Biology; Exome sequencing; Oncology; Gene; Mutation; Internal medicine; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003561421,0.0001837357,0.0005218959,0.00006745558,0.0004697993,0.0001256731,0.0009110169,0.0001616141,0.0004410152],"category_scores_gemma":[0.006031583,0.0001735584,0.0002878138,0.0001054331,0.0007818462,0.00001320482,0.0006630541,0.000491263,0.00002941044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007876218,"about_ca_system_score_gemma":0.001309419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009416639,"about_ca_topic_score_gemma":0.0004646387,"domain_scores_codex":[0.9967589,0.0003136491,0.001128182,0.0006824831,0.0005187452,0.0005979948],"domain_scores_gemma":[0.9963284,0.0006570391,0.0006130789,0.001357428,0.000755139,0.0002888784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00153617,0.001156363,0.2587713,0.0008986236,0.001696625,0.0001140725,0.0001868585,0.001345578,0.6810706,0.0007822145,0.01803608,0.03440553],"study_design_scores_gemma":[0.01008351,0.003898897,0.7868704,0.000900736,0.0005829184,0.00004046433,0.000621474,0.001535957,0.05876869,0.01231325,0.1224622,0.001921527],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930423,0.002434833,0.0001277477,0.0009775072,0.0005780532,0.0005062089,0.0001968396,0.000007615055,0.002128928],"genre_scores_gemma":[0.9910799,0.004865805,0.0007120706,0.0004080908,0.001306571,0.0002364493,0.00002842116,0.00005023686,0.001312511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6223019,"threshold_uncertainty_score":0.7220804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2092261080348713,"score_gpt":0.5197973101985911,"score_spread":0.3105712021637198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}