{"id":"W2741228199","doi":"10.1158/1538-7445.am2017-ct116","title":"Abstract CT116: BMS-986205, an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic (PD) activity, alone and in combination with nivolumab (nivo) in advanced cancers in a phase 1/2a trial","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of British Columbia; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pharmacology; Nivolumab; Pharmacodynamics; In vivo; Pharmacokinetics; Adverse effect; Cancer; Cancer research; Internal medicine; Immunotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008584771,0.0003430675,0.0005424563,0.0008056416,0.0003386842,0.0002455369,0.0005884177,0.0001416923,0.0001187392],"category_scores_gemma":[0.000209862,0.0003039235,0.00003383869,0.0009866161,0.0006359458,0.001274612,0.0001566278,0.001113918,0.000005515853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009943204,"about_ca_system_score_gemma":0.0009426245,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01000663,"about_ca_topic_score_gemma":0.02737657,"domain_scores_codex":[0.9962326,0.0004309553,0.0003930081,0.001105966,0.0009138951,0.0009235775],"domain_scores_gemma":[0.9985864,0.0001925534,0.0002334381,0.0005892368,0.0001377228,0.0002607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2100321,0.002646382,0.0009328575,0.0001386242,0.00001662411,0.0007174668,0.0012415,0.004430421,0.7518383,0.000008255294,0.00008288822,0.02791459],"study_design_scores_gemma":[0.3436225,0.002610754,0.02388992,0.0006020676,0.000004871234,0.00001126566,0.0005268381,0.02126108,0.6066787,0.00005642544,0.0000961599,0.000639424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957929,0.0001398221,0.00001341677,0.0008830166,0.0001297169,0.002565965,0.00006092931,0.00003744555,0.0003768071],"genre_scores_gemma":[0.9983031,0.0005537721,0.00005812703,0.0001241456,0.00005637083,0.0006302497,0.00001201731,0.00005985768,0.0002023976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1451596,"threshold_uncertainty_score":0.9999413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06802588785724402,"score_gpt":0.4034455019186154,"score_spread":0.3354196140613714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}