{"id":"W2741228199","doi":"10.1158/1538-7445.am2017-ct116","title":"Abstract CT116: BMS-986205, an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic (PD) activity, alone and in combination with nivolumab (nivo) in advanced cancers in a phase 1/2a trial","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of British Columbia; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pharmacology; Nivolumab; Pharmacodynamics; In vivo; Pharmacokinetics; Adverse effect; Cancer; Cancer research; Internal medicine; Immunotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002909215,0.0007836,0.0007863321,0.0003054636,0.0002570111,0.0006072205,0.0004538437,0.0006192927,0.008823453],"category_scores_gemma":[0.0002327498,0.0002011343,0.0003883472,0.0003512318,0.0002883727,0.0003794223,0.0002049754,0.002160596,0.001750741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006779507,"about_ca_system_score_gemma":0.0007959036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001073868,"about_ca_topic_score_gemma":0.003175595,"domain_scores_codex":[0.9998506,0.00003078315,0.00001340281,0.00003200212,0.00004216211,0.00003096252],"domain_scores_gemma":[0.9998611,0.00001055404,0.00002584335,0.00001019445,0.00001770318,0.00007453813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1175874,0.01457561,0.005155445,0.001387622,0.0005508636,0.0004921746,0.0001192906,0.002103098,0.6073511,0.0006880098,0.02729031,0.2226991],"study_design_scores_gemma":[0.1604341,0.3310193,0.05809886,0.0002436278,0.0012063,0.002960242,0.0001017123,0.004343531,0.3530754,0.0004354441,0.08799785,0.00008366563],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627611,0.01138058,0.00192968,0.001519529,0.0004808528,0.001589492,0.005062905,0.0006727885,0.01460297],"genre_scores_gemma":[0.9648636,0.004959587,0.002775608,0.0007135351,0.0001773491,0.0005068158,0.0093347,0.00006803536,0.01660081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008823453,"threshold_uncertainty_score":0.02951741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06802588785724402,"score_gpt":0.4034455019186154,"score_spread":0.3354196140613714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}